An interventional study of Protein Supplementation and Aerobic Exercise in Sarcopenia and Muscular Atrophy, sponsored by Liverpool Hope University. Completed at 1 site in United Kingdom. Open to participants aged 60 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-09-11.
Sponsored by Liverpool Hope University · Not applicable, Interventional, and Prevention
Among 72 studies in Sarcopenia with a site in United Kingdom — 11 open to participants now, 14 under way, none of them phase 3. Sarcopenia · United Kingdom.
Among the 72 studies in Sarcopenia with a site in United Kingdom, this one is the 6th largest by enrollment of the 50 interventional ones that give a count, is one of 4 that started in 2016, is one of 44 with no phase, and was the 16th registered.
1,329 studies on the registry are indexed under Sarcopenia; 420 are open to participants now.
Browse Sarcopenia studies →11 of the 72 studies in Sarcopenia with a site in United Kingdom are open now. Recruiting first, the newest first:
University of Nottingham · Sites in United Kingdom
Barts & The London NHS Trust · Sites in United Kingdom
University of Glasgow · Sites in United Kingdom
University of Bath · Sites in United Kingdom
University of Leicester · Sites in United Kingdom
A study can be open while its sites in United Kingdom have not opened yet or have stopped. Only those recruiting at a site in United Kingdom →
Of the 247 Sarcopenia studies recruiting now, 153 (62%) set no upper age limit and 33 (13%) stop at 75 or younger; 9 take children under 18; 65 take healthy volunteers.
This study: 60 Years to 90 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
72 studies; the count open now beside each. This study's row is marked.
First in 2004; this study’s year is marked. 4 started in 2016.
This study's enrollment of 110 is above the median of 60 across 855 interventional studies indexed under Sarcopenia.
Median enrollment 33 across the 50 interventional studies, 132 across the 22 observational. Of the 41 that completed or were terminated, 1 (2%) have results posted.
This tab as a report to print or save as PDF → With an account.
3 of 72 have an industry lead sponsor. The 10 most frequent:
Liverpool Hope University is the lead sponsor of 6 studies on the registry; 1 is open to participants now.
Liverpool Hope University has 1 study filed under Sarcopenia — fewer than ten, so there is no comparison to draw.
2 of the studies in Sarcopenia with a site in United Kingdom that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07127692Medway NHS Foundation TrustPrevalence of Sarcopenia-Promoting Medicines in Patients With Sarcopenia and Falls | 2027-02 |
| NCT07916935The University of NorthamptonEccentric Exercise in Community-dwelling Older Adults | 2027-06-30 |
Among the 72 studies in Sarcopenia with a site in United Kingdom, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This project will investigate the synergistic effects of Aerobic and Resistance type Exercise, in combination with Protein Supplementation, on; Body Composition, Musculoskeletal Functioning, Nutritional Status and Quality of Life in Age-related Sarcopenia.
Musculoskeletal ageing is an inevitable process associated with profound morphological and functional changes that will ultimately transition an individual from independent, to dependable living, relying heavily on personal health care for survival. The United Kingdom (UK) population aged over 65 years is expected to rise from 8.8 to 11.3 million by 2025. As life expectancy increases due to advances in medical treatment, an age-related disease termed sarcopenia, has become more prevalent in the elderly. Sarcopenia, described as the loss of musculoskeletal mass, strength and/or physical functioning with age, manifests after the 6th decade and rapidly increases after the 8th decade, resulting in a deterioration of health status and quality of life. To manage the looming health and economic consequences of sarcopenia, suitable therapeutic strategies to manage the condition are warranted. Therefore, this randomised control trial (RCT) will investigate the effects of 16-weeks of exercise and nutritional interventions in inactive senior citizens (60 - 90 years old).
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
No Intervention
1. Aerobic Exercise i.e. 30-60 minutes per week of moderate intensity exercise 2. Resistance Exercise i.e. 60 minutes per week of progressive resistance training
Other: Aerobic Exercise · Other: Resistance Exercise
1. Aerobic Exercise i.e. 30-60 minutes per week of moderate intensity exercise 2. Dietary Supplement i.e. Protein Supplementation 1.2-1.5g/kg/body weight per day
Dietary Supplement: Protein Supplementation · Other: Aerobic Exercise · Other: Resistance Exercise
Dietary Supplement: Protein Supplementation i.e. 1.2-1.5g/kg/body weight per day
Dietary Supplement: Protein Supplementation
1.2-1.5g/kg/body weight per day
30-60 minutes per week of moderate intensity exercise
60 minutes per week of progressive resistance training
Body Composition: Lean Muscle/Fat Tissue 1) appendicular lean mass (kg) divided by height (meters-squared) and 2) appendicular lean mass divided by body mass index
Time frame: 16 weeks
Grip Strength: Hand Grip Dynanometer (kg)
Time frame: 16 weeks
Gait speed during timed 4-meter walk (m/s)
Time frame: 16 Weeks
Time to complete five chair rises (m/s)
Time frame: 16 Weeks
Balance assessment: 1) feet side to side, 2) semi-tandem, 3) full tandem, and 4) single leg. Scored as Yes or No.
Time frame: 16 Weeks
Isometric Strength - Knee Flexion/Extension: Dynanometer (Nm/Kg)
Time frame: 16 Weeks
Muscle Fatigue: Upper & Lower limb: 25% of MVC during 60 seconds using Electromyography (EMG), measured in millivolts (mV)
Time frame: 16 Weeks
Exercise Tolerance: Six Minute Walk Test (metres)
Time frame: 16 Weeks
10-metre Gait analysis during habitual walking speed using Electromyography (EMG)
Time frame: 16 Weeks
10-metre Gait analysis during habitual walking speed using Three-Dimensional Motion Capture - 1) Spatiotemporal, 2) Kinematics
Time frame: 16 Weeks
Biochemical: Glycated Haemoglobin (HBA1c) (%)
Time frame: 16 Weeks
Biochemical: C-Reactive Protein (CRP) (mg/L)
Time frame: 16 Weeks
Biochemical: Insulin-Like Growth Factor 1 (IGF-1) (ng/ml)
Time frame: 16 Weeks
Arterial Pressure: Pulse Wave Velocity (m/s)
Time frame: 16 Weeks
Energy Balance: Periodic Food Diary (Kcal)
Time frame: 16 Weeks
World Health Organization Quality Of Life Assessment (WHOQOL): Each question is scored from 1-5 on a response scale
Time frame: 16 Weeks
Short-Form Health Survey (SF-12): Each question is scored between 1-6 on a response scale
Time frame: 16 Weeks
Activities of Daily Living (ADL): Each response is scored as either: 0 or 1
Time frame: 16 Weeks
Mini-Mental State Examination (MMSE): Each correct response is scored as 1 point
Time frame: 16 Weeks
Nutritional Status: Mini-Nutritional Assessment (MNA) - Classified as (Low, Moderate, High risk)
Time frame: 16 weeks
Plan to share: Undecided
Ran from Sep 2016 to primary completion in Dec 2023, 87 months.
Of 492 non-industry interventional studies with no phase under Sarcopenia, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 34. This study's 87 months is above that.
Counting every sponsor, half of 503 studies reached it within 18 months; a quarter within 8 and three quarters within 34.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Liverpool Hope University