An interventional study of sugar replacements in Overweight and Obesity, sponsored by Liverpool Hope University. Withdrawn at 1 site in United Kingdom. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2021-05-10.
Sponsored by Liverpool Hope University · Not applicable, Interventional, and Prevention
Among 452 studies in Obesity with a site in United Kingdom — 92 open to participants now, 126 under way, 39 of them phase 3. Obesity · United Kingdom.
Among the 452 studies in Obesity with a site in United Kingdom, this one is the 368th largest by enrollment of the 370 interventional ones that give a count, is one of 12 that started in 2020, is one of 225 with no phase, and was the 249th registered.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
Browse Obesity studies →92 of the 452 studies in Obesity with a site in United Kingdom are open now. Recruiting first, the newest first:
Elenzia · Sites in United Kingdom
StudySetGo · Sites in United Kingdom
Ascletis Pharma (China) Co., Limited · Sites in United Kingdom, United States, Canada and 4 more countries
Ascletis Pharma (China) Co., Limited · Sites in United Kingdom, United States, Czechia and 3 more countries
AstraZeneca · Sites in United Kingdom, United States, Argentina and 8 more countries
A study can be open while its sites in United Kingdom have not opened yet or have stopped. Only those recruiting at a site in United Kingdom →
Of the 1,336 Obesity studies recruiting now, 377 (28%) set no upper age limit and 856 (64%) stop at 75 or younger; 168 take children under 18; 491 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
452 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 31 · Phase 2 36 · Phase 3 75 · Phase 4 12
First in 2001; this study’s year is marked. 12 started in 2020.
Median enrollment 65 across the 370 interventional studies, 130 across the 81 observational. Of the 272 that completed or were terminated, 52 (19%) have results posted.
This tab as a report to print or save as PDF → With an account.
139 of 452 have an industry lead sponsor. The 10 most frequent:
Liverpool Hope University is the lead sponsor of 6 studies on the registry; 1 is open to participants now.
Liverpool Hope University has 2 studies filed under Obesity — fewer than ten, so there is no comparison to draw.
29 of the studies in Obesity with a site in United Kingdom that are under way reach primary completion within a year, 10 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06858839Phase 3AmgenEvaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight | 2027-01-21 |
| NCT06858878Phase 3AmgenEfficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight | 2027-01-21 |
| NCT06672549Phase 3Eli Lilly and CompanyA Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040) | 2027-02 |
| NCT07220642Phase 3Novo Nordisk A/SWeight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide | 2027-05-11 |
| NCT07220759Phase 3Novo Nordisk A/SWeight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide | 2027-05-12 |
Among the 452 studies in Obesity with a site in United Kingdom, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study aims to assess the effect of stevia extract on postprandial glucose and insulin levels in overweight and obese adults when compared to sugar and water.
The study is a three-arm crossover trial involving participants attending the Lab on 3 different occasions (separated by 3-5 day washout period), where they will be administered water, sugar solution (65g), water and stevia extract (5g) solution. The solution will be followed by a consumption of a fixed meal (after 30 minutes). Breakfast will be standardised. Capillary blood glucose will be collected every 30 min until 2 hours post meal. Venous blood samples will be collected before the intake of the solution and at 2 hours after meal intake.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
Browse Obesity studies →Liverpool Hope University is the lead sponsor of 6 studies on the registry; 1 is open to participants now.
Compared within Obesity, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Overweight. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
250 ml of water mixed with 1g of citric acid.
65g of sugar dissolved in 250ml of water
Other: sugar replacements
5g of stevia dissolved in 250ml of water
Other: sugar replacements
Participants will receive a solution of stevia before being administered a fixed meal (lunch). Glucose and insulin levels, and Visual analogue scale data will be collected.
Postprandial glucose levels
Change in glucose levels two hours after the administration of a fixed meal
Time frame: Capillary blood glucose will be measured two hours after the administration of a fixed meal.
Postprandial insulin levels
Change in postprandial insulin levels two hours after the administration of a fixed meal
Time frame: Postprandial insulin levels will be measured two hours of the administration of a fixed meal
Area under the curve (AUC) for glucose
Changes in AUC for glucose throughout the intervention
Time frame: Capillary blood glucose levels will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch
Subjective feelings of satiety
Visual analogue scales
Time frame: VAS will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch.
Plan to share: No
Ran from Mar 2020 to primary completion in Feb 2021, 11 months.
How these figures are worked out, and which studies are left out of them.
This study is withdrawn, as verified in Apr 2020. You cannot join it, but the record below documents what was studied.
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Liverpool Hope University