An interventional study of Periodontal curettes and Er-YAG+Nd-YAG lasers in Chronic Periodontitis, sponsored by Izmir Katip Celebi University. Completed. Open to participants aged 19 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-11-07.
Sponsored by Izmir Katip Celebi University · Not applicable, Interventional, and Treatment
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.
The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planning with hand instruments in nonsurgical treatment of chronic periodontitis.Twenty-five systemically healthy patients with moderate-to-advanced periodontal destruction were selected for this study. The quadrants were randomly allocated in a split-mouth design to either combined Er:YAG (160 mj/pulse, and 10 Hz) and Nd:YAG laser (100 mJ/pulse, and 20 Hz) therapy (test group) or scaling root planning using hand instruments (control group). At baseline, 1 month, and 3 months after treatment, clinical measurements, including plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment level (CAL), and bleeding on probing (%) (BOP), were performed and gingival crevicular fluid and subgingival plaque samples were taken. The gingival crevicular fluid levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were analyzed by enzyme-linked immunosorbent assay. Total antioxidant status (TAS)/total oxidant status (TOS) were analyzed by high-performance liquid chromatography and a novel automatic colorimetric method. Quantitative analysis of Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), and Treponema denticola (Td) was performed using real-time polymerase chain reaction (PCR) procedures.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 25 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →Izmir Katip Celebi University is the lead sponsor of 191 studies on the registry; 40 are open to participants now.
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Exclusion Criteria:
Mechanical periodontal treatment: Scaling and root planing were performed with periodontal curettes until the operator feels that root surface is clean, hard and smooth.
Device: Periodontal curettes
Combined laser therapy: An Er:YAG laser (160 mj/pulse, 10 Hz) (AT Fidelis Fotona, Ljubljana, Slovenia) with water irrigation was first used to remove subgingival calculus and infected cementum.The Er:YAG laser beam was delivered into the periodontal pockets using a chisel-shaped quartz tip in contact mode under water irrigation, from a coronal to an apical direction with the tip inclined at 10o to 15o to the root surfaces. After Er:YAG laser application, Nd:YAG laser treatment (AT Fidelis Fotona, Ljubljana, Slovenia) was performed at an energy level of 100 mJ/pulse, and 20 Hz for removing pocket epithelium and detoxification purpose. Irradiation was accomplished with a 320 μm fiber optic delivery system. The fiber was inserted into the periodontal pocket base in parallel alignment with the root surface, and the fiber was slowly moved from apical to coronal in a sweeping motion during the laser light emission.
Device: Er-YAG+Nd-YAG lasers
Also known as: Hu-Friedy, Gracey curets No. 1/2, 3/4, 5/6, 7/8, 11/12, 13/14, Hu-Friedy Ins. Co., USA
Also known as: AT Fidelis Fotona, Ljubljana, Slovenia
Clinical Attachment Level Change for Moderately Deep Pockets (4 mm≤PD≤6 mm)
Change in clinical attachment level for moderately deep pockets (4 mm≤PD≤6 mm) between baseline and 1 month Change in clinical attachment level for moderately deep pockets (4 mm≤PD≤6 mm) between baseline and 3 month
Time frame: Baseline, 1 and 3 months
Clinical Attachment Level Change for Deep Pockets (7 mm≤PD)
Change in clinical attachment level for deep pockets (7 mm≤PD) between baseline and 1 month. Change in clinical attachment level for deep pockets (7 mm≤PD) between baseline and 3 month.
Time frame: Baseline, 1 and 3 months
| Milestone | Combined Er:YAG and Nd:YAG Laser vs Scaling and Root Planing |
|---|---|
| Started | 25 |
| 1 month | 25 |
| 3 months | 25 |
| Completed | 25 |
| Not completed | 0 |
Change in clinical attachment level for moderately deep pockets (4 mm≤PD≤6 mm) between baseline and 1 month Change in clinical attachment level for moderately deep pockets (4 mm≤PD≤6 mm) between baseline and 3 month
| mm | Control Group | Test Group |
|---|---|---|
| Change in CAL at 1 month | 2.07 ± 0.99 | 2.12 ± 0.97 |
| Change in CAL at 3 months | 2.06 ± 1.04 | 2.09 ± 1.07 |
Change in clinical attachment level for deep pockets (7 mm≤PD) between baseline and 1 month. Change in clinical attachment level for deep pockets (7 mm≤PD) between baseline and 3 month.
| mm | Control Group | Test Group |
|---|---|---|
| Change in CAL at 1 month | 3.74 ± 1.35 | 4.23 ± 0.99 |
| Change in CAL at 3 months | 3.98 ± 1.45 | 4.66 ± 0.93 |
Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Control Group | — | 0/25 (0%) | 0/25 (0%) |
| Test Group | — | 0/25 (0%) | 0/25 (0%) |
| Age, Categorical(Participants) | Combined Er:YAG+ Nd:YAG Laser Versus Scaling Root Planing |
|---|---|
| <=18 years | 0 |
| Between 18 and 65 years | 24 |
| >=65 years | 1 |
| Sex: Female, Male(Participants) | Combined Er:YAG+ Nd:YAG Laser Versus Scaling Root Planing |
|---|---|
| Female | 15 |
| Male | 10 |
| Region of Enrollment(Participants) | Combined Er:YAG+ Nd:YAG Laser Versus Scaling Root Planing |
|---|---|
| Turkey | 25 |
No study locations are listed for this record.
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Izmir Katip Celebi University