An observational study in Healthy and Aging, sponsored by University of Wisconsin, Madison. Completed at 1 site in United States. Open to participants aged 20 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-12-09.
Sponsored by University of Wisconsin, Madison · Observational
Baseline cerebral blood flow through the middle cerebral artery (MCA) and cerebral vasodilator response of the MCA to inhaled carbon dioxide (CO2) will be measured in young women, young men, older women, and older men using Magnetic Resonance (MR) imaging and transcranial Doppler ultrasound (TCD). Data collection techniques will be compared.
The investigators have recently shown that cerebral blood flow responses to chemical stimuli are reduced in healthy older adults. The investigators also have preliminary data suggesting that sex differences in cerebrovascular regulation exist. The overall goal of this application is to extend on the investigators previous studies by employing advanced neuroimaging techniques to enhance the investigators understanding of neurovascular coupling in healthy aging. This study will collect clinically significant data with implications for the future risk of cognitive decline and Alzheimer's disease.
The research aims are:
186 studies on the registry are indexed under Hypercapnia; 34 are open to participants now.
This study's enrollment of 46 is below the median of 52 across 39 observational studies indexed under Hypercapnia.
Browse Hypercapnia studies →University of Wisconsin, Madison is the lead sponsor of 1,161 studies on the registry; 182 are open to participants now.
Of its 151 completed or terminated interventional studies of FDA-regulated products, 114 (75%) have results posted.
Counted across the registry records on this site, refreshed daily.
Subjects for this study will include healthy young adults (20-34 years old) and healthy older adults (50-69 years old). Both men and women will be eligible to participate in this study.
Exclusion Criteria:
Healthy young women between the age of 20-34 years.
Device: MRI · Device: TCD
Healthy young men between the age of 20-34 years.
Device: MRI · Device: TCD
Healthy older women between the age of 50-64 years.
Device: MRI · Device: TCD
Healthy older men between the age of 50-64 years.
Device: MRI · Device: TCD
Participants will undergo a MRI scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory rate and PetCO2 will be measured.
Also known as: Magnetic Resonance Imaging
Participants will undergo a TCD scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory and PetCO2 will be measured.
Also known as: Transcranial Doppler Ultrasound
Middle Cerebral Artery Blood Flow Measurement
Utilize the TCD and MR imaging to measure middle cerebral artery blood flow in the brain while the participant is at rest.
Time frame: 75 minutes
Middle Cerebral Artery Blood Flow Reactivity to Hypercapnia
Utilize the TCD and MR imaging to measure middle cerebral artery blood flow reactivity to hypercapnic gas.
Time frame: 75 minutes
Plan to share: No
This study is completed, as verified in Dec 2019. You cannot join it, but the record below documents what was studied.
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University of Wisconsin, Madison