An interventional study of Dexmedetomidine and NSS in Cervical Spondylosis, sponsored by Mahidol University. Status unknown at 1 site in Thailand. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2016-06-30.
Sponsored by Mahidol University · Not applicable, Interventional, and Treatment
The purpose of this study is to determine the recovery profiles after general anesthesia in patient undergoing anterior cervical spine surgery. This study will compare the Riker sedation agitation scores between two groups, with or without dexmedetomidine as an anesthetic adjuvant.
144 studies on the registry are indexed under Spondylosis; 41 are open to participants now.
This study's planned enrollment of 100 is above the median of 60 across 99 interventional studies indexed under Spondylosis.
Browse Spondylosis studies →Mahidol University is the lead sponsor of 730 studies on the registry; 118 are open to participants now.
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Exclusion Criteria:
Demedetomidine infusion (2mcg/ml); loading 0.5 mcg/kg for 30 min (BW/2 ml/h for 30 min), then 0.5 mcg/kg (BW/4 ml/h) until 30 minutes before finish the operation.
Drug: Dexmedetomidine
NSS loading BW/2 ml/h for 30 min, then BW/4 ml/h until 30 minutes before finish the operation.
Other: NSS
Demedetomidine infusion (2mcg/ml); loading 0.5 mcg/kg for 30 min (BW/2 ml/h for 30 min), then 0.5 mcg/kg (BW/4 ml/h) until 30 minutes before finish the operation.
Also known as: Precedex
NSS infusion; loading BW/2 ml/h for 30 min, then BW/4 ml/h until 30 minutes before finish the operation.
Also known as: Narmal saline, 0.9%NaCl
Riker sedation agitation scores
After finish the operation, Desflurane will be stopped. All patients will be received the neuromuscular reversal drugs and TOF ratio \> 0.9. All patients will be evaluated by Riker sedation agitation score before extubation and re-evaluated again at 15 minutes after extubation. Riker sedation agitation scores 1. Dangerous agitation: trying to get out of bed, pulling out tube, thrashing 2. Very agitated: may require physical restraint, unable to calm with verbal instructions. 3. Agitated: mild agitation and anxiety but calm down with verbal instructions. 4. Calm and cooperative: aroused easily and follows commands 5. Sedated: difficult to aroused, but does arouse to verbal or physical stimuli, able to follow simple commands 6. Very sedated: does not follow commands but arouses to physical stimulation 7. Unarousable: little or no response to noxious stimuli
Time frame: before extubation
Fentanyl consumption
After finish the operation, the total of fentanyl consumption during the operation will be recorded.
Time frame: during surgery
Plan to share: No
This study is status unknown, as verified in Jun 2016. You cannot join it, but the record below documents what was studied.
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Mahidol University