An interventional study of n-Back (Cognitive Training) in Obsessive-Compulsive Disorder, sponsored by University of Stellenbosch. Terminated at 1 site in South Africa. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-05-06.
Sponsored by University of Stellenbosch · Not applicable, Interventional, and Treatment
This unique study will allow us to observe the neural correlates associated with working memory in an obsessive compulsive disorder (OCD) paradigm. We believe that developing working memory in participants suffering with OCD will reduce the severity of their symptomology. This will allow a greater understanding into the functioning of these participants which in turn presents with treatment possibilities.
It is currently unclear whether cognitive training using a working memory task, is effective in reducing obsessive-compulsive symptoms and neuropsychological deficits in patients with OCD. Two groups (OCD and control) will be recruited. Both groups will undergo an intervention consisting of 8 weeks of cognitive training. Working memory, neuropsychological functioning and OCD symptomatology will be assessed pre and post-treatment, in both groups. Furthermore neuroimaging using functional magnetic resonance imaging (fMRI) will be conducted at baseline as well as at the end of the 8 week period in both groups. The scan will serve to show any structural or functional changes in the frontostriatal area involved with working memory. To our knowledge, this is one of the first studies to date to examine whether cognitive training improves symptoms in OCD.
367 studies on the registry are indexed under Compulsive Personality Disorder; 67 are open to participants now.
This study's enrollment of 9 is below the median of 37 across 306 interventional studies indexed under Compulsive Personality Disorder.
Browse Compulsive Personality Disorder studies →University of Stellenbosch is the lead sponsor of 34 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Cognitive Training - n Back.
Behavioral: n-Back (Cognitive Training)
Yale-Brown Obsessive Compulsive Scale (YBOCS)
Time frame: Immediately after intervention
Cambridge neuropsychological test automated battery (CANTAB)
Time frame: Immediately after intervention
Plan to share: No
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This study is terminated, as verified in May 2021. You cannot join it, but the record below documents what was studied.
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Compulsive Personality Disorder→
University of Stellenbosch