An Early Phase 1 interventional study of Light therapy in OCD, sponsored by Washington University School of Medicine. Recruiting at 1 site in United States. Open to participants aged 17 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-18.
Sponsored by Washington University School of Medicine · Early Phase 1, Interventional, and Treatment
The goal of this clinical trial is to test whether light therapy is effective for reducing symptoms in young adults with OCD and late bedtimes (1am or later). The main question[s] it aims to answer are:
Does light therapy reduce OCD symptoms? Does light therapy advance the circadian clock? If there is a comparison group: Researchers will compare a higher dose of light therapy to a lower dose to see if dose amount affects symptom reduction.
Participants will asked to:
Washington University School of Medicine is the lead sponsor of 1,803 studies on the registry; 271 are open to participants now.
Of its 329 completed or terminated interventional studies of FDA-regulated products, 216 (66%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will be given wearable light therapy devices that emit a higher light intensity.
Behavioral: Light therapy
Participants will be given wearable light therapy devices that emit a lower light intensity.
Behavioral: Light therapy
5 weeks of light therapy administered via wearable light therapy glasses worn for 1 hour each morning after awakening.
Yale Brown Obsessive-Compulsive Scale (YBOCS)
A retrospective clinical interview of OCD symptom severity. Score range from 0 to 40 and higher scores indicate more severe OCD symptoms.
Time frame: Administered at baseline, in treatment week 3, and post-treatment (3 administrations over 7 weeks)
Daily Perseverative Thinking Questionnaire
Self-report measure of momentary transdiagnostic repetitive negative thinking. Score range from 6 to 42 and higher scores indicate more severe repetitive negative thinking.
Time frame: Administered 4 times/day for 2 weeks at baseline, 4 times/day for 1 week in treatment week 3, and 4 times/day for 1 week in treatment week 5
Circadian melatonin phase
Dim light melatonin onset assessed by taking hourly saliva samples in dim light conditions for 10 hours beginning 7 hours before typical bedtime and ending 2 hours after typical bedtime.
Time frame: At baseline and post-treatment (after 5 weeks of treament)
Plan to share: Yes
No publications or documents are linked to this record.
Started Dec 2024 (actual). Primary completion is estimated for Mar 2029, 51 months after the start.
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Compulsive Personality Disorder
Washington University School of Medicine →