An interventional study of Détermination and comparison of blood pressure in BLOOD PRESSURE, sponsored by University Hospital, Caen. Status unknown at 1 site in France. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-06-20.
Sponsored by University Hospital, Caen · Not applicable and Interventional
Main objective of the experiment is threefold: 1) to technically test a device for central blood pressure estimation for its applicability in a spaceflight-related environment and on the International Space Station. 2) Furthermore the objective is to compare central blood pressure estimates based on arterial pressure readings of different peripheral arteries. For central blood pressure estimation mathematical transfer functions as described by Karamanoglu and colleagues (11) will be used. 3) Finally the experiments' objective is to simultaneously apply phonocardiography together with ECG and carotid plethysmography to determine cardiac systolic time intervals in parabolic flight during gravity transitions.
Secondary objective of the experiment is to simultaneously measure key variables of the central circulation during gravity transitions to expand the understanding of cardiovascular regulation in weightlessness. Furthermore spirometric measurements shall be performed during a parabolic flight day to observe changes in end-expiratory CO2. Arterial CO2 content is central for cardiovascular regulation.
Our main hypothesis is that there is no difference between different methods of central arteria pressure determination.
Concerning our secondary objective, this experiment is designed as an observational study. Thus no clear hypothesis was generated but the measured cardiovascular and respiratory variables will be analysed regarding differences correlated to gravity.
University Hospital, Caen is the lead sponsor of 505 studies on the registry; 80 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Subjects will be staff member of the team or of other teams participating in the parabolic flight campaign
Exclusion Criteria:
determination and comparison of blood pressure by/with : * Pulse Curve Analysis * Inert gas re-breathing * Central blood pressure device * Vascular ultrasound device * Thoracic Impedance (ICG) - Electrocardiography (ECG) - Phonocardiography (Phono) - Carotid plethysmography (Pneumo)
Other: Détermination and comparison of blood pressure
Rebreathings will be performed every parabola (2, 4, 6, 8, 10...). Ultrasound measurements will be performed during the remaining parabolas (1, 3, 5, 7, 9...). The procedure consists of a fixed breathing frequency of 20 breaths per minute and an exact triggered start point for the measurements. . Central blood pressure measurements, finger blood pressure measurements, impedance cardiography, carotid plethysmography and phonocardiography will be performed continuously during the flights. The breaks between parabolas 10 and 11 and 20 and 21 will be used to change subjects, which takes approximately 5 minutes.
Central arterial pressure
Central arterial pressure evaluated by oscillographic upper arm measurements
Time frame: baseline and when in gravity (same day)
Systolic time intervals
Systolic time intervals evaluated in upright subjects regarding g-load.
Time frame: baseline and when in gravity (same day)
inert gas rebreathing
Cardiac output by inert gas rebreathing
Time frame: baseline and when in gravity (same day)
heart rate
Time frame: baseline and when in gravity (same day)
peripheral blood pressure
Time frame: baseline and when in gravity (same day)
different methods of pulse curve analysis
Cardiac output by different methods of pulse curve analysis will be evaluated for different g-loads.
Time frame: baseline and when in gravity (same day)
Plan to share: No
No publications or documents are linked to this record.
This study is status unknown, as verified in Jun 2016. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University Hospital, Caen