An observational study in Depressed, sponsored by Dr. Kate Harkness. Completed at 1 site in Canada. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-08-28.
Sponsored by Dr. Kate Harkness · Observational
The goal of this project is to learn more about the different ways in which people process information that is stressful and rewarding, and how abnormalities in these two processes are related to depression.
Participants will participate in two 3-hour sessions separated by a week at Providence Care, Mental Health Services, and a third, 1.5-hour session at the Queen's MRI Facility. At the first session participants will complete a packet of questionnaires about their mood and take part in an interview about their mood, medications, drug use, and any other symptoms, as well as an interview about their relationships with their parents and any experiences of abuse. At the second session participants will participate in a stress test, which involves giving a speech to a panel. The investigators will also collect saliva samples to look at stress hormones. Participants will also complete a task on the computer that involves looking at cartoon faces and making decisions about them. At the third session, the investigators take images of of participant's brain using a magnetic resonance scanner.
Participants are invited to participate in a 6-month follow-up for this study, which would involve the same procedure as outline above.
8,057 studies on the registry are indexed under Depression; 1,641 are open to participants now.
This study's enrollment of 219 is above the median of 160 across 1,084 observational studies indexed under Depression.
Browse Depression studies →This is the only study on the registry with Dr. Kate Harkness as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Community sample
For Depressed Participants:
Inclusion Criteria:
Exclusion Criteria:
For Healthy Control Participants:
Inclusion Criteria:
Exclusion Criteria:
No intervention
No intervention
Stress Sensitivity: Salivary Hormone and Stress Challenge Test (TSST)
Participants are required to give a speech and an arithmetic test in front of a panel. Saliva samples are collected at 8 points throughout the test.
Time frame: 2 hours after beginning of Time B Appointment
Mood and Anxiety Symptom Questionnaire (MASQ)
Self-report scale of general distress (GD), anhedonic depression (AD), and anxious arousal (AA) symptoms
Time frame: Administered at first baseline appointment and covers past 2 weeks
Reward Responsivity: Probabilistic Reward Task
Computerized task that requires participants to choose between two stimuli and develop a response bias to the more frequently rewarded stimulus.
Time frame: Administered at second baseline appointment
Snaith Hamilton Pleasure Scale (SHAPS and SHAPS-C)
Self-report of anhedonia symptoms
Time frame: Administered at first baseline appointment and covers past 2 weeks prior to interview
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2019. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.