An observational study in Depression, sponsored by Centre Hospitalier Universitaire de Nice. Completed at 1 site in France. Open to participants aged 40 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-06-17.
Sponsored by Centre Hospitalier Universitaire de Nice · Observational
Patients with depression are frequently treatment resistant. Clinical manifestations of depression are various, but cognitive dysfunctions are commonly present. Many factors are involved in treatment resistance. As no biological marker is available, clinical markers could be considered in predicting response to antidepressive treatment.
The aim of this study is to investigate the relation between the cognitive changes and the remission of depressive symptoms in patients with recurrent depression (Stage 2 of Thase and Rush classification).
To explore the dynamics of cognitive dimension associated to clinical and functional remission, the investigators will observe neurocognitive functioning before and after introducing a new antidepressive therapy.
8,057 studies on the registry are indexed under Depression; 1,641 are open to participants now.
This study's enrollment of 30 is below the median of 160 across 1,084 observational studies indexed under Depression.
Browse Depression studies →Centre Hospitalier Universitaire de Nice is the lead sponsor of 709 studies on the registry; 176 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with a major depressive episode diagnosis
Exclusion Criteria:
Clinic assessments: Score BDI - II
The investigators will conduct clinical assessments. A baseline will be drawn in the acute phase (V1) before modifying the antidepressive therapy; 2 weeks after treatment change, patient will be clinically assessed by his psychiatrist. A complete assessment will be done 6 months and 12 months after introducing the new therapy.
Time frame: Change from the baseline score BDI-II at 12 months after introducing the new therapy
Functional assessments : Score Sheehan Disability Scale (SDS)
The investigators will conduct functional assessments. A baseline will be drawn in the acute phase (V1) before modifying the antidepressive therapy; 2 weeks after treatment change, patient will be functional assessed by his psychiatrist. A complete assessment will be done 6 months and 12 months after introducing the new therapy.
Time frame: Change from the baseline Score Sheehan Disability Scale (SDS) at 12 months after introducing the new therapy
Neuropsychologic assessments: M.M.S.E. (Mini Mental Score Evaluation)
The investigators will conduct neuropsychologic assessments. A baseline will be drawn in the acute phase (V1) before modifying the antidepressive therapy; A complete assessment will be done 6 months and 12 months after introducing the new therapy.
Time frame: Change from the baseline Score M.M.S.E. (Mini Mental Score Evaluation) at 12 months after introducing the new therapy
Plan to share: No
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Centre Hospitalier Universitaire de Nice