An observational study in Acute Coronary Syndrome, sponsored by The First Affiliated Hospital of Dalian Medical University. Completed at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2017-08-01.
Sponsored by The First Affiliated Hospital of Dalian Medical University · Observational
This study valuates the serum Tenascin-C concentration in patients with acute coronary syndrome.
It is found that Tenascin-C plays an important role in ventricular remodeling, heart failure, aortic dissection, rheumatic heart disease and other cardiovascular diseases, which may be a new marker for the diagnosis and prognosis prediction of these diseases. However, there is few relevant studies about the Tenascin-C concentration in patients with acute coronary syndrome.This study valuates the serum Tenascin-C concentration in patients with acute coronary syndrome.
1,461 studies on the registry are indexed under Acute Coronary Syndrome; 267 are open to participants now.
This study's enrollment of 183 is below the median of 500 across 561 observational studies indexed under Acute Coronary Syndrome.
Browse Acute Coronary Syndrome studies →The First Affiliated Hospital of Dalian Medical University is the lead sponsor of 41 studies on the registry; 10 are open to participants now.
Counted across the registry records on this site, refreshed daily.
patients with acute coronary syndrome,including STEMI,non-STEMI,and UAP patients.
.diagnosed as acute coronary syndrome,including STEMI,non-STEMI,and UAP.
Exclusion Criteria:
The study population consists of 30 patients with ST-elevated acute myocardial infarction (STEMI,n = 30) who are admitted within 24 hours after chest pain attack. They will all undergo coronary angiography. The diagnosis is made according to American Heart Association (AHA, 2014 and 2015) guidelines. Patients who had autoimmune diseases, malignancies, chronic or acute infections, asthma, severe heart failure (NYHA class 3 and 4) and advanced liver or renal diseases are excluded.
The study population consists of 30 patients with non-ST elevated acute myocardial infarction (NSTEMI,n=30) who are admitted within 24 hours after chest pain attack. They will all undergo coronary angiography. The diagnosis is made according to American Heart Association (AHA, 2014 and 2015) guidelines. Patients who had autoimmune diseases, malignancies, chronic or acute infections, asthma, severe heart failure (NYHA class 3 and 4) and advanced liver or renal diseases are excluded.
The study population consists of 30 patients with unstable angina pectoris (UAP, n = 30). They will all undergo coronary angiography for the diagnosis of acute coronary syndrome. The diagnosis is made according to the criteria of the American Heart Association (AHA, 2014 and 2015). Patients who had autoimmune diseases, malignancies, chronic or acute infections, asthma, severe heart failure (NYHA class 3 and 4) and advanced liver or renal diseases are excluded.
15 age and body mass index matched healthy subjects with neither coronary artery disease nor any of the components of the metabolic syndrome are studied as Normal group.
Serum Tenascin-C concentration
Serum Tenascin-C concentration in ng/ml
Time frame: 12 months
Relationship between Tenascin-C and high sensitive C reaction protein (hs-CRP) concentration
With or without association between them
Time frame: 12 months
Relationship between Tenascin-C and Troponin-I (Tn-I) concentration
With or without association between them
Time frame: 12 months
MACEs during 12-month follow-up
All major adverse cardiac events( MACEs) including death, myocardial infarction, angina, heart failure are recorded.
Time frame: 12 months
Plan to share: No
This study is completed, as verified in Jul 2017. You cannot join it, but the record below documents what was studied.
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The First Affiliated Hospital of Dalian Medical University