An interventional study of Phonological and Orthographic in Aphasia, Primary Progressive, Anomia and Alzheimer Disease, sponsored by Georgetown University. Completed at 2 sites in United States. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2024-09-25.
Sponsored by Georgetown University · Not applicable, Interventional, and Treatment
The goal of this study is to remediate word-finding problems in patients who have Primary Progressive Aphasia (PPA) or Alzheimer's Disease and to delay the further progression of word-finding impairment. The current approach is novel in that it contains a prophylaxis component in which the investigators attempt to strengthen neural connections that remain functional, making them more resistant to degradation as the disease progresses. While the study is specific in its targeting of word-finding problems, a successful outcome would bode well for other studies aimed at prevention or reversal of declining cognitive functions in dementia. One set of participants with PPA will receive practice with picture naming in two conditions: viewing the picture and repeating the name; and viewing the picture with its written name, plus reading and writing the name. Another set of participants with PPA or Alzheimer's Disease will be trained in two different conditions: learning about the word's semantic features (meaning); and learning about the word's lexical features (letters and sounds). Naming of pictures trained in each of these conditions will be compared, at three time intervals post-training, with naming of pictures tested before the study but never trained. It is predicted that the pairing of the picture with its written name, combined with the motor task of writing the name, will result in a greater ability to name the picture at a later date than simple practice viewing the picture and repeating the name. Furthermore, it is predicted that participants who have difficulty understanding concepts will be more likely to respond to semantic treatment, while participants who have difficulty connecting words with concepts will be more likely to respond to lexical treatment.
77 studies on the registry are indexed under Aphasia, Primary Progressive; 29 are open to participants now.
This study's enrollment of 84 is above the median of 30 across 60 interventional studies indexed under Aphasia, Primary Progressive.
Browse Aphasia, Primary Progressive studies →Georgetown University is the lead sponsor of 292 studies on the registry; 40 are open to participants now.
Of its 28 completed or terminated interventional studies of FDA-regulated products, 20 (71%) have results posted.
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Exclusion Criteria:
Behavioral: Phonological · Behavioral: Orthographic · Behavioral: Untrained
Behavioral: Semantic · Behavioral: Lexical · Behavioral: Untrained
This treatment involves picture viewing and word repetition.
This treatment involves picture viewing, reading, and writing.
This treatment involves learning about the semantic features (meaning) of each trained word.
This treatment involves learning about the lexical features (letters and sounds) of each trained word.
These words are not trained during the treatment phase.
Change in picture naming accuracy for words within each treatment condition during treatment
The change in picture naming accuracy for trained words will be compared with the change in picture naming accuracy for words that were tested at baseline but never trained during the treatment phase.
Time frame: baseline, 7 months
Change in picture naming accuracy for words within each treatment condition between baseline and first follow-up assessment
The change in picture naming accuracy for trained words will be compared with the change in picture naming accuracy for words that were tested at baseline but never trained during the treatment phase.
Time frame: baseline, 14 months
Change in picture naming accuracy for words within each treatment condition between baseline and second follow-up assessment
The change in picture naming accuracy for trained words will be compared with the change in picture naming accuracy for words that were tested at baseline but never trained during the treatment phase.
Time frame: baseline, 21 months
This study is completed, as verified in Sep 2024. You cannot join it, but the record below documents what was studied.
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Aphasia, Primary Progressive →