CClinicalTrials.gg
Active, not recruitingNCT02650843NMDATUpdated Apr 13, 2025

Non-motor Symptoms and Brain Dopamine Transporter Binding

An observational study in Parkinson Disease and Parkinsonism, sponsored by Turku University Hospital. Active, not recruiting. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2025-04-13.

Sponsored by Turku University Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
455
Ages
18 Years to 100 Years
Sex
All
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Study summary

This project aims to clarify the role non-motor symptoms in the development of Parkinson's disease (PD) and to improve diagnostics at very early stages of PD. The project involves multidimensional measures of disease biomarkers together with brain dopamine transporter (DAT) imaging with [123I]FP-CIT single photon emission computed tomography (SPECT).

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Conditions studied

  • Parkinson Disease
  • Parkinsonism

Keywords

  • Parkinsonism
  • DAT Dopamine transporter
  • SPECT
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In context

Parkinson Disease

4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.

This study's enrollment of 455 is above the median of 96 across 1,057 observational studies indexed under Parkinson Disease.

Browse Parkinson Disease studies →

Lead sponsor

Turku University Hospital is the lead sponsor of 280 studies on the registry; 65 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with parkinsonism

Eligibility criteria

Inclusion Criteria:

  • Male or Female
  • Age 18-100 years
  • Referred for clinical DAT SPECT in Turku or Helsinki
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
455 participants (actual)
Patient registry
No

Groups and cohorts

  • Patients with parkinsonism

    Patients with parkinsonism that are referred for DAT SPECT imaging in Turku University Hospital, Finland or Helsinki University Hospital, Finland

    Other: DAT SPECT imaging

Interventions

  • OtherDAT SPECT imaging
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What researchers measure

Primary outcomes

  1. DAT SPECT striatal specific binding ratio

    Time frame: Up to 10 years

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Eklund M, Nuuttila S, Joutsa J, Jaakkola E, Makinen E, Honkanen EA, Lindholm K, Vahlberg T, Noponen T, Ihalainen T, Murtomaki K, Nojonen T, Levo R, Mertsalmi T, Scheperjans F, Kaasinen V. Diagnostic value of micrographia in Parkinson's disease: a study with [123I]FP-CIT SPECT. J Neural Transm (Vienna). 2022 Jul;129(7):895-904. doi: 10.1007/s00702-022-02517-1. Epub 2022 May 27. PubMed 35624405 ↗
  • Nuuttila S, Eklund M, Joutsa J, Jaakkola E, Makinen E, Honkanen EA, Lindholm K, Noponen T, Ihalainen T, Murtomaki K, Nojonen T, Levo R, Mertsalmi T, Scheperjans F, Kaasinen V. Diagnostic accuracy of glabellar tap sign for Parkinson's disease. J Neural Transm (Vienna). 2021 Nov;128(11):1655-1661. doi: 10.1007/s00702-021-02391-3. Epub 2021 Jul 30. PubMed 34328563 ↗

Individual participant data

Plan to share: Undecided

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 13, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02650843
Lead sponsor
Turku University Hospital
Collaborators
Helsinki University Central Hospital
Responsible party
Sponsor
First posted
Jan 8, 2016
Start date
Jan 2015
Primary completion
Dec 2026 (estimated)
Completion
Dec 2026 (estimated)
Last update
Apr 13, 2025

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.

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Discussion

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