An observational study in Critical Illness, Sepsis and Acute Kidney Injury, sponsored by Heinrich-Heine University, Duesseldorf. Status unknown at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-05-07.
Sponsored by Heinrich-Heine University, Duesseldorf · Observational
Cytokine adsorption using the cytosorb adsorber is currently investigated to reduce the levels of proinflammatory cytokines in patients with severe sepsis and septic shock. The adsorber is frequently used in series with continuous renal replacement therapy. Up to date, no data on the removal of antibiotic drugs during combined renal replacement therapy and cytokine adsorptive therapy is available. Therefore, we want to investigate
Patients in this trial are undergoing renal replacement therapy as part of their routine care. Thus, this is an observational trial.
1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.
This study's planned enrollment of 30 is below the median of 160 across 931 observational studies indexed under Sepsis.
Browse Sepsis studies →Heinrich-Heine University, Duesseldorf is the lead sponsor of 174 studies on the registry; 52 are open to participants now.
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Critically ill patients treated for sepsis on surgical intensive care unit undergoing renal replacement therapy.
Exclusion Criteria:
Critically ill patients teated with piperacillin/tazobactam undergoing renal replacement therapy and cytosorb absorption during sepsis
Other: Monitoring of antibiotic drug removal
Critically ill patients teated with imipenem/cilastatin undergoing renal replacement therapy and cytosorb absorption during sepsis
Other: Monitoring of antibiotic drug removal
No study specific intervention will be performed
Removal of antibiotic drugs during the first 8 hours of combined continuous renal replacement therapy and cytosorb adsorption
Removal of antibiotic drugs during combined CRRT and adsorption will be evaluated by calculating total filter clearance using the drug concentration pre- and postfilter as well as the dialysate concentration. The adsorptive clearance will be evaluated using the pre- and postadsorber concentration. The outcome measure will be removal of antibiotic drug \[mg/8 h dosing interval\].
Time frame: 8 hours
This study is status unknown, as verified in May 2020. You cannot join it, but the record below documents what was studied.
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Heinrich-Heine University, Duesseldorf