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Status unknownNCT02592122Updated Oct 30, 2015

Airway Responsiveness in Patients With AECOPD Mechanical Ventilation by Inspiratory and Bronchial Dilation Testchronic Obstructive Pulmonary Disease

An interventional study of Salbutamol Aerosol and No drugs in Lung Disease,Obstructive, sponsored by snow. Status unknown at 1 site in China. Per ClinicalTrials.gov, last updated 2015-10-30.

Sponsored by snow · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Oct 2015), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Sex
All
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Study summary

In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.

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Conditions studied

  • Lung Disease,Obstructive

Keywords

  • Mechanical ventilation
  • Chronic obstructive pulmonary disease
  • Airway resistance
  • Bronchial dilation test
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In context

Lung Diseases, Obstructive

2,592 studies on the registry are indexed under Lung Diseases, Obstructive; 198 are open to participants now.

This study's planned enrollment of 120 is above the median of 66 across 1,837 interventional studies indexed under Lung Diseases, Obstructive.

Browse Lung Diseases, Obstructive studies →

Lead sponsor

This is the only study on the registry with snow as lead sponsor.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Acute exacerbation of chronic obstructive pulmonary disease
  • The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours

Exclusion criteria

Exclusion Criteria:

  • asthma
  • has received tracheotomy
  • long term mechanical ventilation (which has been accepted for more than 21 days).
  • severe pneumonia
  • Patients who cannot use a patient with bronchial dilation
  • there's a taboo on the use of a sedative.
  • refusal to participate in the study
  • 48 hours to pull out the tube
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
120 participants (estimated)

Study arms

  • Active comparator
    Atomization inhalation

    First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Second, randomly selected into the atomization group

    Drug: Salbutamol Aerosol

  • Active comparator
    Without atomization inhalation

    First of all, investigators need to give patients to do the test, the result is more than 12% is positive group, less than 12% is negative group.Secondly, the random selection is not the atomization group

    Drug: No drugs

Interventions

  • DrugSalbutamol Aerosol

    Also known as: Ammonium bromide bromide aerosol

  • DrugNo drugs
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What researchers measure

Primary outcomes

  1. airway resistance

    The first test of bronchial dilatation

    Time frame: 1 day

  2. Respiratory mechanics index:PEEPi

    Time frame: 1 day

Secondary outcomes

  1. Mechanical ventilation time

    Time frame: 28 days

  2. length of hospital stay

    Time frame: 30 days

  3. Costs of hospitalization expenses

    Time frame: 30 days

  4. Routine blood test:Eosinophilic cells

    Time frame: 7days

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Study locations

1 of 1 sites recruiting
  • Department of respiratory and critical care medicine,Beijing Chao-yang Hospital
    Beijing, Beijing 100020, China
    Recruiting
08

References and documents

Publications

  • Li Y, Chen Y, Wang P. Application of impulse oscillometry and bronchial dilation test for analysis in patients with asthma and chronic obstructive pulmonary disease. Int J Clin Exp Med. 2015 Jan 15;8(1):1271-5. eCollection 2015. PubMed 25785124 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 30, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02592122
Lead sponsor
snow
Collaborators
Primary-investigator,Bing Sun
Responsible party
snow (Beijing Chao Yang Hospital) — Sponsor-investigator
First posted
Oct 30, 2015
Start date
Oct 2013
Primary completion
Oct 2016 (estimated)
Last update
Oct 30, 2015

Study contacts

Xue Wang, MB
Contact
rtxue2013@sina.com
0086-10-85231543
Sun Bing, MD
Contact
ricusunbing@126.com
86013911151075
Bing Sun
principal investigator · Beijing Chao Yang Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Oct 2015. You cannot join it, but the record below documents what was studied.

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