An observational study in Acute Pulmonary Insufficiency Following Thoracic Surgery and Ventilator-associated Lung Injury, sponsored by National Taiwan University Hospital. Status unknown at 1 site in Taiwan. Open to participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2016-05-25.
Sponsored by National Taiwan University Hospital · Observational
Acute lung injury (ALI) following thoracic surgery remains a major source of morbidity and mortality after lung resection. One-lung ventilation (OLV) is usually required in thoracic surgery. OLV is also an important predictor of postoperative ALI. Recent laboratory findings suggested that tissue hypoxemia and ischemia / reperfusion injury of the collapsed lungs during OLV is the major cause of lung injury. Exhaled Breath Condensate (EBC), which is the exhalate from breath typically collected by cooling device, contains most molecules found in the airway. Metabolomics refers to systematic and scientific study of chemical processes involving metabolites. This study will collect EBC for metabolomic analysis and aim to elucidate the biochemical reactions during one-lung ventilation and pathological mechanisms of acute lung injury following thoracic surgery.
Acute lung injury (ALI) following thoracic surgery remains a major source of morbidity and mortality after lung resection. Despite the advancement in both the surgical techniques and the perioperative management, the incidence of postoperative ALI remains remarkable. Risk factors for postoperative lung injury are evident, including preoperative pulmonary function, type of surgical procedure, intraoperative fluid management, one-lung ventilation, and ventilator settings. One-lung ventilation (OLV) is usually required in thoracic surgery. OLV is also an important predictor of postoperative ALI. Recent laboratory findings suggested that tissue hypoxemia and ischemia / reperfusion injury of the collapsed lungs during OLV is the major cause of lung injury. Exhaled Breath Condensate (EBC), which is the exhalate from breath typically collected by cooling device, contains most molecules found in the airway. EBC analysis has potential applications in lung disease, such as severity of airway inflammation in asthmatic patients. Collecting EBC is simple and non-invasive, in contrast to bronchoscopy for lung biopsy or bronchoalveolar lavage. Metabolomics refers to systematic and scientific study of chemical processes involving metabolites. This study will collect EBC from thoracic surgical patients before, during, and after OLV. The investigators will perform metabolomic analysis and aim to elucidate the biochemical reactions during one-lung ventilation and pathological mechanisms of acute lung injury following thoracic surgery.
399 studies on the registry are indexed under Lung Injury; 50 are open to participants now.
This study's planned enrollment of 40 is below the median of 70 across 136 observational studies indexed under Lung Injury.
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Thoracic surgical patients requiring lung isolation
Exclusion Criteria:
General anesthesia and lung separation Thoracic Surgery with Lung Resection, such as lobectomy, segmentectomy
Procedure: Thoracic Surgery with Lung Resection
General anesthesia and lung separation Thoracic Surgery without Lung Resection, such as esophageal surgery, mediastinal surgery
Procedure: Thoracic Surgery without Lung Resection
General anesthesia and lung separation Thoracic surgery with lung resection, such as lobectomy, segmentectomy
General anesthesia and lung separation Thoracic surgery without lung resection, such as esophageal surgery, mediastinal surgery
Number of participants with acute lung injury following thoracic surgery
Time frame: 30 days
Metabolome of exhaled breath condensate associated with lung injury in thoracic surgery
Time frame: 5 hours
This study is status unknown, as verified in May 2016. You cannot join it, but the record below documents what was studied.
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National Taiwan University Hospital