An interventional study of scaling and root planing in Cardiovascular Disease in Obstructive Sleep Apnea, sponsored by Hopital Foch. Terminated at 1 site in France. Open to participants aged 30 Years to 70 Years. Per ClinicalTrials.gov, last updated 2018-10-03.
Sponsored by Hopital Foch · Not applicable, Interventional, and Treatment
Evaluation of the add-on effect on endothelial dysfunction of treatment of periodontitis in patients with chronic periodontitis and severe obstructive sleep apnea treated by CPAP. Patients with and without chronic periodontitis will be treated by CPAP for 20 weeks. At V2 (10 weeks), endothelial dysfunction will be assessed by the Reactive Hyperemia- Peripheral Artery Tone index. The endothelial dysfunction of the patients will be also assessed at V3 (20 weeks) after periodontitis treatment for the group of patients with chronic periodontitis.
At V2, patients with periodontitis will have full-mouth intensive removal of denatl plaque biofilms with the use of scaling and root planing. The add-on effect of the periodontitis treatment on endothelial dysfunction will be assessed ten weeks later (V3) in comparison with V2 by taking into account with the effect of 10 weeks of CPAP in the control group with severe OSA but not periodontitis.
1,422 studies on the registry are indexed under Apnea; 159 are open to participants now.
This study's enrollment of 49 is close to the median of 50 across 965 interventional studies indexed under Apnea.
Browse Apnea studies →Hopital Foch is the lead sponsor of 208 studies on the registry; 21 are open to participants now.
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Exclusion Criteria:
patients with severe obstructive sleep apnea (OSA) and chronic parodontis treated for OSA by continuous positive airway pressure (CPAP) and intensive periodontal treatment
Procedure: scaling and root planing
patients with severe OSA treated by CPAP
full-mouth intensive removal of subgingival dental plaque biofilms with the use of scaling and root planing after the administration of local anesthesia
Endothelial function
measure of Reactive Hyperemia- Peripheral Artery Tone index with Endopat
Time frame: 20 weeks
Endothelial function
measure of Reactive Hyperemia- Peripheral Artery Tone index with Endopat
Time frame: 10 weeks
blood biomarkers
hsCRP, leptin, adiponectin, E-selectin and orosomucoid
Time frame: 0, 10 and 20 weeks
Epworth Sleepiness Scale
Time frame: 0, 10 and 20 weeks
This study is terminated, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.
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Hopital Foch