An interventional study of Remifentanil and sevoflurane 1 in Ischemic Heart Disease, sponsored by Konkuk University Medical Center. Completed at 1 site in South Korea. Open to participants aged 19 Years to 72 Years. Per ClinicalTrials.gov, last updated 2015-07-16.
Sponsored by Konkuk University Medical Center · Not applicable, Interventional, and Treatment
In patients undergoing off-pump coronary artery bypass (OPCAB) surgery with different anesthesia regimens: remifentanil (0.75 mcg/kg/min) and propofol (TCI effect-site concentration 0.8-1.5 mcg/ml) (Group -RP); remifentanil (0.75 mcg/kg/min) and sevoflurane (end-tidal 0.8 vol%) (Group-RS), or sevoflurane (end-tidal 1.2-2.8 vol%)-sufentanil (TCI effect site concentration 0.35-0.75 ng/ml) (Group-SS), intergroup difference in the level of Troponin I (c-TnI) and creatinine kinase subtype-MB is determined before surgery (control), during vascular graft harvesting (harvesting), after completing graft construction (postgrafting), and one day after surgery (postoperative).
To determine the difference of myocardial injury upon using different anesthesia regimens: remifentanil-based regimen versus sevoflurane-sufentanil balanced regimen.
Patients undergoing off-pump coronary artery bypass (OPCAB) surgery are randomly allocated to get remifentanil (0.75 mcg/kg/min) and propofol (TCI effect-site concentration 0.8-1.5 mcg/ml) (Group -RP), remifentanil (0.75 mcg/kg/min) and sevoflurane (end-tidal 0.8 vol%) (Group-RS), or sevoflurane (end-tidal 1.2-2.8 vol%)-sufentanil (TCI effect site concentration0.35-0.75 ng/ml) (Group-SS).
Intergroup difference in the level of Troponin I (c-TnI) and creatine kinase-MB is determined before surgery (control), during vascular graft harvesting (harvesting), after completing graft construction (postgrafting), 1 day after surgery (postoperative).
3,242 studies on the registry are indexed under Myocardial Ischemia; 390 are open to participants now.
This study's enrollment of 120 is close to the median of 120 across 1,901 interventional studies indexed under Myocardial Ischemia.
Browse Myocardial Ischemia studies →Konkuk University Medical Center is the lead sponsor of 95 studies on the registry; 16 are open to participants now.
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Exclusion Criteria:
remifentanil (0.75 mcg/kg/min) propofol (TCI effect-site concentration 0.8-1.5 mcg/ml)
Drug: Remifentanil · Drug: propofol
remifentanil (0.75 mcg/kg/min) sevoflurane (end-tidal 0.8 vol%)
Drug: Remifentanil · Drug: sevoflurane 1
sevoflurane (end-tidal 1.2-2.8 vol%)-sufentanil (TCI effect site concentration 0.35-0.75 ng/ml)
Drug: sevoflurane 2 · Drug: sufentanil
administering remifentanil for anesthesia maintenance
administering sevoflurane 1 for anesthesia maintenance
administering sevoflurane 2 for anesthesia maintenance
administering propofol for anesthesia maintenance
administering sufentanil for anesthesia maintenance
troponin I
troponin I for myocardial injury
Time frame: one day after surgery
creatinin kinase-MB
creatinine kinase-MB
Time frame: one day after surgery
This study is completed, as verified in Jul 2015. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Remifentanil · Propofol · Sufentanil
Konkuk University Medical Center