An observational study in Xerostomia, Hyperthyroidism and Thyroid Cancer, sponsored by Boston Children's Hospital. Completed at 1 site in United States. Open to participants aged 3 Years to 55 Years. Per ClinicalTrials.gov, last updated 2017-06-26.
Sponsored by Boston Children's Hospital · Observational
Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease.
Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease. We will use a Modified Shirmer Test to measure saliva production and a questionnaire to evaluation symptoms of xerostomia.
264 studies on the registry are indexed under Xerostomia; 48 are open to participants now.
This study's enrollment of 70 is below the median of 100 across 33 observational studies indexed under Xerostomia.
Browse Xerostomia studies →Boston Children's Hospital is the lead sponsor of 608 studies on the registry; 149 are open to participants now.
Of its 33 completed or terminated interventional studies of FDA-regulated products, 19 (58%) have results posted.
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Patients who have receive I-131 therapy in childhood for thyroid disease, compared to a control group of patients who have never receive I-131 therapy
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Exclusion Criteria:
Patients with a history of childhood treatment with radioiodine will be assessed for symptoms of salivary function and measurement of saliva production. These data will be compared to a normal control group.
Other: Radioiodine
Patients who are similar in age to those in the Radioiodine group, but who did not recieve I-131 therapy.
We will determine if prior radioiodine treatment in childhood impacts salivary function or symptoms. Radioiodine treatment will have been determined by the patient's medical condition and care (NOT assigned by this research study).
Salivary function (MST value)
sterile paper strip is used to measure saliva production (noninvasive testing)
Time frame: 0 to 50 years after radioiodine treatment
Responses to Dry Mouth Questionnaire
Patient questionnaire/survey
Time frame: At time of visit up to 4 months thereafter.
Caries history (number of caries noted in dental records)
Time frame: 1 year before radioiodine administration to 4 months after study visit.
This study is completed, as verified in Jun 2017. You cannot join it, but the record below documents what was studied.
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