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CompletedNCT02368366Updated Jan 29, 2018

Comparative Effectiveness of Family Problem-Solving Therapy (F-PST) for Adolescent TBI

An interventional study of Therapist Guided Face to Face Family Problem Solving and Therapist Guided Online Family Problem Solving in Tbi, Intracranial Edema and Brain Edema, sponsored by Children's Hospital Medical Center, Cincinnati. Completed at 5 sites in United States. Open to participants aged 14 Years to 19 Years. Per ClinicalTrials.gov, last updated 2018-01-29.

Sponsored by Children's Hospital Medical Center, Cincinnati · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
151
Allocation
Randomized
Ages
14 Years to 19 Years
Sex
All
01

Study summary

Traumatic brain injury (TBI) is the most common cause of acquired disability in youth and a source of significant morbidity and family burden. Novel behavior problems are among the most common and problematic consequences, yet many youth fail to receive needed psychological services due to lack of identification and access. Linking youth with TBI to effective treatments could improve functional outcomes, reduce family burden, and increase treatment satisfaction. The investigators overarching aim is to compare the effectiveness, feasibility, and acceptability of three formats of family problem solving therapy (F-PST) for improving functional outcomes of complicated mild to severe adolescent TBI: therapist-guided, face-to-face; therapist-guided online; and self-guided, online F-PST.

Read the detailed description

Background: Traumatic brain injury (TBI) is the most common cause of acquired disability in youth and a source of significant morbidity and family burden. Novel behavior problems are among the most common and problematic consequences, yet many youth fail to receive needed psychological services due to lack of identification and access. Linking youth with TBI to effective treatments could improve functional outcomes, reduce family burden, and increase treatment satisfaction.

Methods: The investigators overarching aim is to compare the effectiveness, feasibility, and acceptability of three formats of family problem solving therapy (F-PST) for improving functional outcomes of complicated mild to severe adolescent TBI: therapist-guided, face-to-face; therapist-guided online; and self-guided, online F-PST. The efficacy of face-to-face and online F-PST in reducing behavior problems following TBI has been established. However, their comparative acceptability and effectiveness are unknown and it is unclear if families could also benefit from online F-PST without therapist support. To identify which patients benefit most from each intervention, participants will be stratified by distance from the clinic with patients living more than 20 miles or 60 minutes from the clinic randomized to one of the two online arms and others equally randomized among three arms. Patient-reported outcomes pertaining to child, caregiver, and family functioning along with patient treatment preferences will be assessed: prior to treatment initiation, at treatment completion, and at a follow-up 3 months later. Stakeholder input (adolescents with TBI and their caregivers) will guide measurement selection and refinements to the treatment protocols. Each treatment modality consists of 10-14 sessions addressing TBI education, problem-solving, self-regulation, and family communication, but varies in the nature and extent of therapist involvement. Participants will include families of 120 adolescents age 14-18 recruited from four metropolitan TBI centers. Mixed models analyses will be used to examine group differences in improvements in child behavior/functioning, caregiver distress, and family burden. Moderators of comparative effectiveness including socioeconomic status, prior technology use, and patient preferences will be examined.

Anticipated Impact: Results will elucidate the relative effectiveness of face-to-face versus online and self-directed versus therapist-supported online modes of treatment including patient and family preferences. They will also provide information about how these programs can be delivered and disseminated through existing head injury follow-up clinics. These data could potentially be translated to other patient populations of youth with psychological symptoms arising from neurological conditions.

02

Conditions studied

  • Tbi
  • Intracranial Edema
  • Brain Edema
  • Craniocerebral Trauma
  • Head Injury
  • Brain Hemorrhage, Traumatic
  • Subdural Hematoma
  • Brain Concussion
  • Head Injuries, Closed
  • Epidural Hematoma
  • Cortical Contusion
  • Wounds and Injuries
  • Disorders of Environmental Origin
  • Trauma, Nervous System
  • Brain Injuries
03

Who can participate

Ages eligible
14 Years to 19 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Moderate to severe TBI
  • Overnight hospital stay
  • English-speaking
  • Parent must be willing to provide informed consent

Exclusion criteria

Exclusion Criteria:

  • Child does not live with parents or guardian
  • Child or parent has history of hospitalization for psychiatric problem
  • Child suffered a non-blunt injury (e.g., projectile wound, stroke, drowning, or other form of asphyxiation)
  • Diagnosed with moderate or severe mental retardation, autism, or a significant developmental disability
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
151 participants (actual)

Study arms

  • Experimental
    Therapist Guided Face to Face FPST

    Therapist Guided Face to Face Family Problem Solving Families assigned to this arm will meet with the therapist in person at the medical center TBI clinic. Sessions will last approximately 60 minutes and cover didactic content using printed handouts provided as part of a family workbook.

    Behavioral: Therapist Guided Face to Face Family Problem Solving

  • Experimental
    Therapist Guided Online FPST

    Therapist Guided Online Family Problem Solving Families assigned to this arm will receive a password enabling them to access the online intervention materials throughout the course of the intervention. Each session of online F-PST consists of a self-guided online portion providing didactic content regarding the desired skill (i.e., problem-solving), video clips showing individuals and families modeling the skill, and exercises and assignments giving the family an opportunity to practice the skill. During synchronous, videoconference sessions with the therapist, the family will review the online materials and practice the problem-solving process.

    Behavioral: Therapist Guided Online Family Problem Solving

  • Experimental
    Self-Guided Online FPST

    Self-Guided Online Family Problem Solving Families in the self-guided, online F-PST arm will receive a password enabling them to access the online intervention materials throughout the course of the intervention. They will receive access to the same web-modules as the therapist-guided group, but will review them on their own without therapist support. Participants in this group will be encouraged to complete web modules at the same schedule as participants in the other groups. If the family fails to log on or complete web modules, they will receive reminders via phone, text, or e-mail.

    Behavioral: Self-Guided Online Family Problem Solving

Interventions

  • BehavioralTherapist Guided Face to Face Family Problem Solving

    Families assigned to this arm will meet with the therapist in person at the medical center TBI clinic. Sessions will last approximately 60 minutes and cover didactic content using printed handouts provided as part of a family workbook.

  • BehavioralTherapist Guided Online Family Problem Solving

    Families assigned to this arm will receive a password enabling them to access the online intervention materials throughout the course of the intervention. Each session of online F-PST consists of a self-guided online portion providing didactic content regarding the desired skill (i.e., problem-solving), video clips showing individuals and families modeling the skill, and exercises and assignments giving the family an opportunity to practice the skill. During synchronous, videoconference sessions with the therapist, the family will review the online materials and practice the problem-solving process.

  • BehavioralSelf-Guided Online Family Problem Solving

    Families in the self-guided, online F-PST arm will receive a password enabling them to access the online intervention materials throughout the course of the intervention. They will receive access to the same web-modules as the therapist-guided group, but will review them on their own without therapist support. Participants in this group will be encouraged to complete web modules at the same schedule as participants in the other groups. If the family fails to log on or complete web modules, they will receive reminders via phone, text, or e-mail.

05

What researchers measure

Primary outcomes

  1. Behavior Rating Inventory of Executive Function (BRIEF)

    Time frame: Baseline, post-intervention and 3 months post-intervention

Secondary outcomes

  1. Center for Epidemiology Scale for Depression (CES-D)

    Time frame: Baseline, post-intervention and 3 months post-intervention

  2. Health and Behavior Inventory (HBI)

    Time frame: Baseline, post-intervention and 3 months post-intervention

  3. Ohio State University (OSU) Traumatic Brain Injury (TBI) Identification Method (OSU TBI-ID)

    Time frame: Baseline

  4. Brief Symptom Inventory (BSI)

    Time frame: Baseline, post-intervention and 3 months post-intervention

  5. Strengths and Difficulties Questionnaire (SDQ)

    Time frame: Baseline, post-intervention and 3 months post-intervention

  6. Pediatric Quality of Life Inventory (PedsQL)

    Time frame: Baseline, post-intervention and 3 months post-intervention

06

Study locations

5 sites
  • The Children's Hospital
    Denver, Colorado 80045, United States
  • Cincinnati Children's Hospital Medical Center
    Cincinnati, Ohio 45229, United States
  • Case Western Reserve University
    Cleveland, Ohio 44106, United States
  • MetroHealth Medical Center
    Cleveland, Ohio 44106, United States
  • Nationwide Children's Hospital
    Columbus, Ohio 43205, United States
07

References and documents

Publications

  • Wade SL, Cassedy AE, Taylor HG, McNally KA, Kirkwood MW, Stancin T, Horn PS, Kurowski BG. Adolescent quality of life following family problem-solving treatment for brain injury. J Consult Clin Psychol. 2019 Nov;87(11):1043-1055. doi: 10.1037/ccp0000440. Epub 2019 Sep 26. PubMed 31556652 ↗
08

Registry details

Key details

Study ID
NCT02368366
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Collaborators
Case Western Reserve University, Children's Hospital Colorado, MetroHealth Medical Center, Nationwide Children's Hospital, Patient-Centered Outcomes Research Institute
Responsible party
Sponsor
First posted
Feb 23, 2015
Start date
Nov 2014
Primary completion
Nov 2017
Completion
Nov 2017
Last update
Jan 29, 2018

Study contacts

Shari Wade, PhD
principal investigator · Children's Hospital Medical Center, Cincinnati

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

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