An observational study in Mild Cognitive Impairment, Mild Dementia and Moderate Dementia, sponsored by University Hospital, Angers. Status unknown at 1 site in France. Open to participants aged 60 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-01-29.
Sponsored by University Hospital, Angers · Observational
The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.
Gait disorders are frequent in individuals with cognitive disorders. However, the profile of spatio-temporal gait parameters in the different cognitive status in aging (from normal cognition to dementia) has been poorly studied. Determining this profile associated with the severity of cognitive disorders may be helpful to understand the complex interplay between gait and cognitive disorders and, thus, may have important implication for the diagnosis process of patients with and without dementia. For instance, defining a motor phenotype of the severity of cognitive disorders by using quantitative gait measurements could be used to improve the prediction and the diagnosis of dementia.
The investigators hypothesized that, compared to CHI, people with MCI and mild dementia could be characterized by specific phenotypes of spatio-temporal gait parameters measured with the GAITRite® system, and that these profiles could be explained by declines in domain-specific cognitive performance.
2,172 studies on the registry are indexed under Dementia; 540 are open to participants now.
This study's planned enrollment of 2,800 is above the median of 250 across 482 observational studies indexed under Dementia.
Browse Dementia studies →University Hospital, Angers is the lead sponsor of 464 studies on the registry; 116 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients were recruited in each memory clinic by a physician
Exclusion Criteria:
CHI were participants without objective cognitive impairment
Other: gait and cognitive testing
MCI was diagnosed if participants met the following criteria: presence of spontaneous cognitive complaints and objective cognitive impairment
Other: gait and cognitive testing
Diagnoses of dementia were assigned according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV TR, 2000; Association, 2000; 22) at consensus diagnostic case conferences
Other: gait and cognitive testing
Spatio-temporal gait parameters
Spatio-temporal gait parameters were measured at steady state walking using GAITRite®-system.
Time frame: This outcome is assessed at inclusion
Clinical assessment
This outcome was assessed by a questionnaire.
Time frame: This outcome is assessed at inclusion
Cognitive status
Cognitive status was assessed by cognitive testing.
Time frame: This outcome is assessed at inclusion
This study is status unknown, as verified in Feb 2014. You cannot join it, but the record below documents what was studied.
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University Hospital, Angers