An observational study in Rhinosinusitis, sponsored by First Affiliated Hospital of Chongqing Medical University. Status unknown at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2014-12-25.
Sponsored by First Affiliated Hospital of Chongqing Medical University · Observational
This study aimed to evaluate the upstream events of Th17/Treg imbalance in CRS and their immune regulatory factors. Then the investigators aimed to explore the regulatory role of miRNA on DC-Th axis and its dysfunction in the pathogenesis of CRS, in order to determine the miRNA expression profile in CRS and clarify the role of miRNA in the pathogenesis of CRS by regulating the DC-Th axis.
Chronic rhinosinusitis (CRS), commonly encountered in the field of clinical otorhinolaryngology, is still a challenging proposition for doctors because of its high incidence and the unsatisfactory treatment outcomes. Nowadays, studies on the pathogenesis of NP are still attached great importance by researchers from each country. NP has become a global health problem with a considerable socioeconomic burden. Recently, research showed that the impaired balance of Th17/Treg was the significant basis of NP. Nevertheless, the pathogenesis of Th17/Treg imbalance was unclear. In this study, DC-Th axis was designed as the main line, and the regulation of miRNA on DC was designed as the entry point. This study aimed to evaluate the upstream events of Th17/Treg imbalance in CRS and their immune regulatory factors. Then the investigators aimed to explore the regulatory role of miRNA on DC-Th axis and its dysfunction in the pathogenesis of CRS, in order to determine the miRNA expression profile in CRS and clarify the role of miRNA in the pathogenesis of CRS by regulating the DC-Th axis. This study will play an important role in clarifying the pathogenesis of CRS eventually and will fill the blanks of the research between miRNA and CRS in the investigators'country. This study is with important clinical value for establishing control strategies for CRS.
330 studies on the registry are indexed under Rhinosinusitis; 55 are open to participants now.
This study's planned enrollment of 70 is below the median of 100 across 81 observational studies indexed under Rhinosinusitis.
Browse Rhinosinusitis studies →First Affiliated Hospital of Chongqing Medical University is the lead sponsor of 95 studies on the registry; 42 are open to participants now.
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Participants will be selected from the department of endoscopic sinus surgery in the First Affiliated Hospital of Chongqing Medical University.
Exclusion Criteria:
Patients with only nasal septum deviation
Genetic: miRNA mimics or inhibitors
Chronic Rhinosinusitis patients without nasal polyps
Genetic: miRNA mimics or inhibitors
Chronic Rhinosinusitis patients with allergic constitution and nasal polyps
Genetic: miRNA mimics or inhibitors
Chronic Rhinosinusitis patients with nasal polyps but not allergic constitution
Genetic: miRNA mimics or inhibitors
DCs are transfected by the miRNA mimics or inhibitors after they are separated from peripheral blood mononuclear cells in CRS patients
Abnormal microRNA in the Chronic Rhinosinusitis are found by gene chip and qPCR.
Time frame: 6 to 24 months post procedure
This study is status unknown, as verified in Dec 2014. You cannot join it, but the record below documents what was studied.
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First Affiliated Hospital of Chongqing Medical University