An interventional study of soft drinks in Healthy, sponsored by University of Hohenheim. Completed at 1 site in Germany. Open to male participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-11-18.
Sponsored by University of Hohenheim · Not applicable, Interventional, and Prevention
Aim of the study is to investigate the impact of glycemic index (provided as soft drinks) on changes in insulin sensitivity, metabolic flexibility, and arterial stiffness in response to detraining.
The investigators hypothesize that low glycemic soft drinks decrease the detraining-induced impairment of insulin sensitivity, metabolic flexibility and arterial stiffness.
The duration of the study is 7 weeks: two x 2 weeks intervention (phase A and phase B) with 3 weeks washout phase inbetween. Each 2-week intervention phase consists of an active week followed by an inactive week.
in phase A subjects consume high GI (maltodextrin and sucrose) soft drinks during the inactive week. In phase B subjects consume a low GI soft drink (palatinose) during the inactive week.
subjects were randomly assigned to either start with phase A or with phase B (cross over design).
During the whole study duration all food is provided (55% CHO, 30% fat, 15% protein)
Physical activity will be assessed by a step counter (active phase 7000-10000 steps/d and inactive phase 3000-4000 steps/d).
368 studies on the registry are indexed under Sedentary Behavior; 165 are open to participants now.
This study's enrollment of 16 is below the median of 70 across 314 interventional studies indexed under Sedentary Behavior.
Browse Sedentary Behavior studies →University of Hohenheim is the lead sponsor of 43 studies on the registry; 2 are open to participants now.
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Exclusion Criteria:
palatinose in soft drinks
Dietary Supplement: soft drinks
sucrose plus maltodextrin in soft drinks
Dietary Supplement: soft drinks
soft drinks with palatinose and maltodextrin
Influence of GI on inactivity-induced changes in insulin sensitivity as measured by an OGTT
Influence of GI (glycemic index) on detraining-induced changes (difference between the end of high activity and low activity phases) in insulin sensitivity Insulin sensitivity is assessed by HOMA and Matsuda indices
Time frame: the difference between the end of each 1 week activity phase (day 7 vs. day 14, low vs. high physical activity) is compared between high GI and low GI intervention
Influence of GI on inactivity-induced changes in metabolic flexibility as measured by indirect calorimetry (RER, respiratory exchange ratio)
Impact of GI on inactivity induced changes in metabolic flexibility Metabolic flexibility is defined as the body´s ability to adapt fuel oxidation to changing fuel availability and energy demand It is measured as change in fasting RER (fasting metabolic flexibility) and change in RQ (difference between the end of high activity and low activity phases) after an oral glucose tolerance test (postprandial metabolic flexibility)
Time frame: the difference between the end of each 1 week activity phase (day 7 vs. day 14) is compared between high GI and low GI intervention
Influence of GI on inactivity-induced changes in parameters of arterial stiffness as measured by pulse wave velocity
impact of GI on inactivity-induced changes (difference between the end of high activity and low activity phases) in arterial stiffness (as assessed by pulse wave velocity)
Time frame: the difference between the end of each 1 week activity phase (day 7 vs. day 14) is compared between high GI and low GI intervention
The record gives a start of Aug 2014, a primary completion of Jun 2015 and a completion of Sep 2015. It does not say whether these dates are actual or estimated.
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This study is completed, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.
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University of Hohenheim