An interventional study of Test meal in Obesity and Normal Weigth, sponsored by University of Hohenheim. Completed at 1 site in Germany. Open to participants aged 25 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-08-06.
Sponsored by University of Hohenheim · Not applicable, Interventional, and Basic science
After eating, blood composition changes, including increased triglycerides and glucose, which can trigger postprandial inflammation. Particularly with high-fat foods, pro-inflammatory lipopolysaccharide (LPS) increases. This activates leukocytes to release pro-inflammatory cytokines. In industrialized countries where "snacking" is common, many people spend the day in a postprandial state. Obese individuals tend to have chronic inflammation and show increased susceptibility to infections such as SARS-CoV-2. The main objective of the study is to investigate the response of leukocytes and the serum metabolome after food intake in individuals with obesity compared to healthy individuals, focusing on LPS as a key stimulus of innate immunity.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's enrollment of 38 is below the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →University of Hohenheim is the lead sponsor of 43 studies on the registry; 2 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Investigational drug or device
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Test meal
Other: Test meal
Test meal
Other: Test meal
Test meal consisting of fries, chicken nuggets and eggs
LPS
LPS in Serum
Time frame: 30 min after test meal
LPS
LPS in Serum
Time frame: 60 min after test meal
LPS
LPS in Serum
Time frame: 120 min after test meal
LPS
LPS in Serum
Time frame: 180 min after test meal
LPS
LPS in Serum
Time frame: 240 min after test meal
Activability of PBMCs in vitro
To analyze the reactivity of PBMCs, these are isolated, co-cultivated with bacteria and then the number of replicable bacteria is counted.
Time frame: immediately after the intervention
Serum cytokines and PAMPs
Time frame: immediately after the intervention
Characterization of PBMCs
The PBMCs are characterized by fluorescence-activated cell sorting (FACS) and RNA isolation.
Time frame: immediately after the intervention
Metabolome analyses
Time frame: immediately after the intervention
Trimethylamine / SCFA in serum
Time frame: immediately after the intervention
Fasting blood glucose
Time frame: immediately after the intervention
lipoproteins
Time frame: immediately after the intervention
HbA1c
Time frame: immediately after the intervention
Microbiome RNA in serum
Time frame: baseline
IgA in serum
Time frame: immediately after the intervention
Fecal microbiome analysis
Time frame: baseline
Plan to share: Undecided — Case-by-case decision after contact
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.
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University of Hohenheim