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CompletedNCT02308215Updated Aug 30, 2019

Retinal Therapy Guided by 3D OCT Image Analysis

An observational study in Age-Related Macular Degeneration and Choroidal Neovascularization, sponsored by Michael Abramoff. Completed at 1 site in United States. Open to participants aged 45 Years to 120 Years. Per ClinicalTrials.gov, last updated 2019-08-30.

Sponsored by Michael Abramoff · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
77
Ages
45 Years to 120 Years
Sex
All
01

Study summary

The main purpose is to find a better way to predict the timing of treatments given to patients with Wet Age-related macular degeneration using image analysis.

Read the detailed description

The study focuses on making better use of advanced three-dimensional imaging and analysis to allow physicians to know when a treatment is being effective and thus not overuse it. The study will examine how 3-D optical coherence tomography and related image analysis can be used to assess changes in the macula and retina of patients' eyes. These changes can reveal how well a person is responding to anti-VEGF treatment and thus help doctors provide proper treatment timing and care.

02

Conditions studied

  • Age-Related Macular Degeneration
  • Choroidal Neovascularization

Keywords

  • Retina
  • AMD
  • OCT
03

In context

Macular Degeneration

1,474 studies on the registry are indexed under Macular Degeneration; 206 are open to participants now.

This study's enrollment of 77 is below the median of 106 across 421 observational studies indexed under Macular Degeneration.

Browse Macular Degeneration studies →

Lead sponsor

This is the only study on the registry with Michael Abramoff as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
45 Years to 120 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The proposed research will be carried out in patients diagnosed with Choroidal Neovascularization associated with AMD selected from retina care clinic.

Inclusion criteria

  • fundoscopically confirmed AMD and patient eligible for treatment with anti-VEGF

Exclusion criteria

Exclusion Criteria:

  • Patients with a CNV due to other causes (OHS, trauma)
  • eyes that have been previously treated for CNV
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
77 participants (actual)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Measure central retinal layer thickness in µms.

    Time frame: one year

  2. Measure amount of fluid in the retina in µms.

    Time frame: one year

07

Study locations

1 site
  • University of Iowa Hospitals Dept of Ophthalmology
    Iowa City, Iowa 52246, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 30, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02308215
Lead sponsor
Michael Abramoff
Collaborators
National Eye Institute (NEI)
Responsible party
Michael Abramoff (Professor, University of Iowa) — Sponsor-investigator
First posted
Dec 4, 2014
Start date
Jul 2010
Primary completion
Jul 5, 2018
Completion
Jul 5, 2018
Last update
Aug 30, 2019

Study contacts

Michael D Abramoff, MD, PhD
principal investigator · University of Iowa
Milan Sonka, MS, PhD
principal investigator · University of Iowa

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2019. You cannot join it, but the record below documents what was studied.

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