An interventional study of Speed of Processing Training (SPT) and Placebo Control in Multiple Sclerosis, sponsored by Kessler Foundation. Completed at 1 site in United States. Open to participants aged 18 Years to 59 Years. Per ClinicalTrials.gov, last updated 2020-02-20.
Sponsored by Kessler Foundation · Not applicable, Interventional, and Treatment
The purpose of this research study is to investigate the effectiveness of a computerized technique designed to improve processing speed (i.e. the amount of time it takes for a person's brain to process information) in a multiple sclerosis (MS) population. The study is designed to study how well this technique can help people with MS increase their processing speed and their ability to function better in everyday life. This treatment protocol has been studied extensively with older adults, showing improvements on standard laboratory measures of processing speed and performance of activities of daily living.
This study is a double-blind, placebo-control randomized clinical trial examining the efficacy of Speed of Processing Training (SPT) for improving processing speed (PS) deficits in persons with Multiple Sclerosis (MS). Slowed PS is one of the most common deficits in individuals with MS and such deficits have been shown to exert significant negative impact on multiple aspects of everyday life, including occupational and social functioning. Despite these findings, few studies have attempted to remediate PS deficits in order to improve the everyday functioning of individuals with MS. This study is designed to (1) apply a treatment protocol for PS impairments well-validated in an aging population to individuals with MS with objectively observable deficits in PS and document its efficacy on standard neuropsychological outcome measures. In addition, the investigators will (2) assess the effectiveness of the intervention utilizing global measures of everyday life, including an objective measure (the Timed Activities of Daily Living; TIADL), as well as additional questionnaires to be completed by both the participant and a significant other. This study is also designed to (3) examine the influence of degree of PS impairment on treatment efficacy using neuropsychological tests, (4) evaluate the long-term effects of the treatment protocol and (5) examine the utility of booster sessions to facilitate long-term treatment effects.
3,460 studies on the registry are indexed under Multiple Sclerosis; 661 are open to participants now.
This study's enrollment of 100 is above the median of 50 across 2,342 interventional studies indexed under Multiple Sclerosis.
Browse Multiple Sclerosis studies →Kessler Foundation is the lead sponsor of 170 studies on the registry; 58 are open to participants now.
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Exclusion Criteria:
SPT will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).
Behavioral: Speed of Processing Training (SPT)
Placebo control exercises will be administered on a laptop computer twice a week for 5 weeks (10 sessions)
Behavioral: Placebo Control
Placebo control exercises will be administered on a laptop computer twice a week for 5 weeks (10 training sessions).
Change in scores on standardized tests of processing speed
Time frame: Three points in time: baseline (week1), immediately following treatment (week 7) and 6 months after treatment is completed
Change in scores on self-report of emotional functioning, measured via questionnaire
Self-report questionnaires and objective measures of everyday performance will be used to determine whether there have been changes across the three time points.
Time frame: Three points in time: baseline (week1), immediately following treatment (week 7) and 6 months after treatment is completed
Change in scores on self-report of everyday functioning, measured via questionnaire
Time frame: Three points in time: pre-treatment, immediately following treatment and 6 months after treatment is completed
Change in scores on self-report of quality of life, measured via questionnaire
Time frame: Three points in time: baseline (week1), immediately following treatment (week 7) and 6 months after treatment is completed
This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.
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Kessler Foundation