An observational study in Fatty Liver and Gestational Diabetes, sponsored by Seoul National University Hospital. Status unknown at 3 sites in Korea, Republic of. Open to female participants. Per ClinicalTrials.gov, last updated 2020-03-20.
Sponsored by Seoul National University Hospital · Observational
The aim of this study is to evaluate the prevalence of metabolic syndrome, liver function abnormality and non-alcoholic fatty liver disease in early pregnancy patients, and the risk of pregnancy complications.
In cases in which metabolic syndrome and non-alcoholic fatty liver are risk factors of obstetric complications, such as gestational diabetes (GDM) or preeclampsia (PE), we are able to offer systematic clinical results from determining the independent risk factor and developing a predictable model. Recently, obstetric complications, especially GDM and PE, have increased due to the growth of elder pregnancy. In addition, as liver dysfunction has been known to be an independent risk factor of diabetes, cardiovascular disease, high blood pressure and renal dysfunction, its clinical importance has risen. Metabolic syndromes, such as obesity, hypertension, type II diabetes and abnormal lipid profile, have been known for its importance in development of non-alcoholic fatty liver disease. Considering abnormal liver function being an independent risk factor of diabetes, cardiovascular disease, high blood pressure and renal dysfunction in normal adult patients, we are able to predict that liver dysfunction might be a high risk factor of obstetric complications in pregnant women. In previous studies, the frequency of liver dysfunction in normal pregnant women was obtained.
The purpose of this current study was to investigate the prevalence of metabolic syndrome, abnormal liver function and non-alcoholic fatty liver in early pregnancy and the related risks of obstetric complications.
1,451 studies on the registry are indexed under Fatty Liver; 292 are open to participants now.
This study's planned enrollment of 2,400 is above the median of 140 across 397 observational studies indexed under Fatty Liver.
Browse Fatty Liver studies →Seoul National University Hospital is the lead sponsor of 1,860 studies on the registry; 275 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
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1st trimester pregnancy women with singleton
Exclusion Criteria:
For evaluate whether fatty liver is exist or not
Compare prevalence of obstetric complications between non-alcoholic fatty liver and normal pregnant women
Obstetrical complications include gestational diabetes, preeclampsia, etc Non-alcoholic fatty liver diagnosed by using liver ultrasound result of 1st trimester and blood test (AST, APT)
Time frame: From date of enrollment until the date of delivery, assessed up to 35wks
This study is status unknown, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.
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Seoul National University Hospital