An observational study in Brain Injury, sponsored by University Hospital, Clermont-Ferrand. Completed at 1 site in France. Open to participants aged 15 Years and older. Per ClinicalTrials.gov, last updated 2015-10-15.
Sponsored by University Hospital, Clermont-Ferrand · Observational
Identification of criteria associated with extubation failure of brain injured patients. Elaboration of a prognostic score of extubation failure of brain injured patients.
Prospective clinical study in ICU with brain injured ventilated patients eligible to extubation.
Identification of clinical and biological criteria associated with failure of extubation.
Elaboration of a prognostic score of extubation failure of brain injured patients, based on criteria previously identified with multivariate analysis.
Failure of extubation is defined by the need of re-intubation or the need for non-invasive ventilation within 48 hours or more after extubation.
2,113 studies on the registry are indexed under Brain Injuries; 385 are open to participants now.
This study's enrollment of 140 is above the median of 100 across 690 observational studies indexed under Brain Injuries.
Browse Brain Injuries studies →University Hospital, Clermont-Ferrand is the lead sponsor of 841 studies on the registry; 178 are open to participants now.
Counted across the registry records on this site, refreshed daily.
brain injured patients
Exclusion Criteria:
Status epilepticus
Other: weaning trial of mechanical ventilation
Failure of extubation defined by the need of reintubation or the need for non-invasive ventilation
- Failure of extubation defined by the need of reintubation or the need for non-invasive ventilation within 48 hours or during ICU stay
Time frame: at day 2
Severity scores (SAPS II, SOFA, GCS…) ) at patient admission in ICU
Time frame: at ady 1
Cause of brain injury (traumatic, ischemic, hemorrhagic or post-operative) at patient admission in ICU
Time frame: at day 1
Localisation of brain injury (hemispheric, supra- or sub-tentorial) at patient admission in ICU
Time frame: at day 1
Complete neurological examination (Glasgow score, Coma Recovery Scale, FOUR score, cough, brain stem reflexes) just before extubation
Time frame: at day 1
cardiologic history (cardiac insufficiency or ischemic cardiomyopathy) during ICU stay
Time frame: at day 1
- Pulmonary examination (arterial gasometry, ventilatory parameters: mode, frequency, positive end expiratory pressure, inspiratory pressure, tidal volume, minute ventilation, oxygen level) just before extubation
Time frame: at day 1
- Cause of extubation failure before 48 hours (respiratory, hemodynamic, aspiration, ...)
Time frame: at day 2
Delay of extubation from intubation day (number of days)
Time frame: at day 1
Glasgow Outcome Score (GOS)
Time frame: at 6 months
This study is completed, as verified in Oct 2015. You cannot join it, but the record below documents what was studied.
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University Hospital, Clermont-Ferrand