CClinicalTrials.gg
Status unknownNCT02218398Updated Aug 18, 2014

Bronchodilator Test in Mechanical Ventilated Chronic Obstructive Pulmonary Disease Patients

An interventional study of Albuterol in Chronic Obstructive Pulmonary Disease, sponsored by Beijing Chao Yang Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2014-08-18.

Sponsored by Beijing Chao Yang Hospital · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Aug 2014), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Ages
18 Years to 90 Years
Sex
All
01

Study summary

Investigators developed a test to assess the bronchodilator effects in mechanically ventilated chronic obstructive pulmonary disease patients by comparing the change of airway resistance. No matter whether patients respond to bronchodilator or not, they are randomized assigned to bronchodilator 3-4 times per day group and no bronchodilator group. Then investigators could objectively decide whether individual patients need or benefit from bronchodilator administration.

Read the detailed description

Bronchodilator is commonly used in mechanical ventilated chronic obstructive pulmonary disease patients. It is assumed that patient's response to bronchodilator is the same during acute exacerbation or when stable whether on mechanical ventilation or not. Decision to treat is often independent of response and the patient's response to the medicine is not precisely evaluated. Investigators developed a test to assess the bronchodilator effects in mechanically ventilated chronic obstructive pulmonary disease patients by comparing the change of airway resistance. No matter whether patients respond to bronchodilator or not, they are randomized assigned to bronchodilator 3-4 times per day group and no bronchodilator group. Then investigators could objectively decide whether individual patients need or benefit from bronchodilator administration.

02

Conditions studied

  • Chronic Obstructive Pulmonary Disease

Keywords

  • airway resistance
  • lung compliance
  • Duration of mechanical ventilation
03

In context

Lung Diseases

3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.

This study's planned enrollment of 120 is above the median of 72 across 2,118 interventional studies indexed under Lung Diseases.

Browse Lung Diseases studies →

Lead sponsor

Beijing Chao Yang Hospital is the lead sponsor of 135 studies on the registry; 49 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

should meet all the criteria:

  1. Acute exacerbated chronic obstructive pulmonary disease
  2. Invasive mechanical ventilation with intubation outside ICU no more than 48 hours

Exclusion criteria

Exclusion Criteria:

Meet any of the criteria:

  1. Asthma
  2. Tracheotomy
  3. Prolonged Mechanical Ventilation (Have been mechanical ventilated for more than 21 days)
  4. Unstable hemodynamic status
  5. Severe pneumonia
  6. Contraindication for bronchodilator
  7. Contraindication for sedation
  8. Refusal to participate in study
  9. Re-intubation in 48 hours
  10. Mental disorder, could not understand and accomplish pulmonary function test
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
120 participants (estimated)

Study arms

  • Experimental
    Bronchodilator

    Albuterol 3-4 times per day, steroids when necessary.

    Drug: Albuterol

  • No intervention
    No drug

    No drug

Interventions

  • DrugAlbuterol
06

What researchers measure

Primary outcomes

  1. Percentage of 12% Decrease in airway resistance

    Time frame: 30 minutes

Secondary outcomes

  1. Duration of mechanical ventilation

    Time frame: participants will be followed for the duration of ICU stay, an expected average of 28 days

07

Study locations

1 of 1 sites recruiting
  • Respiratory Intensive Care Unit, Beijing Chaoyang Hospital
    Beijing, Beijing 101100, China
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 18, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT02218398
Lead sponsor
Beijing Chao Yang Hospital
Collaborators
First Affiliated Hospital of Chongqing Medical University
Responsible party
Jie Li (RRT-NPS, Beijing Chao Yang Hospital) — Principal investigator
First posted
Aug 18, 2014
Start date
May 2013
Primary completion
Jun 2015 (estimated)
Completion
Dec 2015 (estimated)
Last update
Aug 18, 2014

Study contacts

Jie Li, Master
Contact
lijie8497@hotmail.com
86-13552976483

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Aug 2014. You cannot join it, but the record below documents what was studied.

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