An observational study in Acne, sponsored by University of California, Davis. Completed at 2 sites in United States. Open to participants aged 12 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-05-30.
Sponsored by University of California, Davis · Observational
The purpose of this study is to evaluate the differences in the skin lipid profile of patients with and without acne. Secondly, the goal is to learn more about what the effects of retinoinds (topical and systemic) are on the the skin lipid profile. We hypothesize that the skin lipid profile of subjects with acne will be lower in inflammatory lipids in comparison to subjects without acne.
Skin lipid profile will be conducted via sebutapes- adhesive tapes that painlessly absorbs sebum from the face. These tapes will be placed on the face for 1 hour. A photograph of the face will be taken during each study visit. A sebumeter will also be used to measure skin sebum secretion rate.
730 studies on the registry are indexed under Acne Vulgaris; 86 are open to participants now.
This study's enrollment of 30 is below the median of 90 across 81 observational studies indexed under Acne Vulgaris.
Browse Acne Vulgaris studies →University of California, Davis is the lead sponsor of 798 studies on the registry; 146 are open to participants now.
Of its 65 completed or terminated interventional studies of FDA-regulated products, 43 (66%) have results posted.
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Subjects will be from the UC Davis Dermatology Clinic, surrounding dermatology clinics, from the UC Davis undergraduate campus, and from the California State University Sacramento campus.
Exclusion Criteria:
The subjects in this group do not have a history of acne.
These subjects have been prescribed a topical retinoid for their acne. They will participate in the study for a period of 1 month.
Drug: Tretinoin or Adapalene
These subjects have been prescribed isotretinoin for their acne. They will participate in the study for a period of 5-6 months.
Drug: Isotretinoin
Subjects will apply a pea sized amount of topical retinoid cream once daily at night for 30 days. Subjects will return for a follow-up visit.
Also known as: Retin A
Subjects will take one pill once daily for 5 months. Subjects will return after 1 month and after 4-5 months of treatment for skin lipid profiling.
Also known as: Accutane
Skin lipid profile of acne and healthy patients
Compare the skin lipid profile of acne and healthy patients at baseline
Time frame: baseline visit
Skin lipid profile of acne patients after treatment
Patients in the topical retinoid group will have their lipids evaluated after 1 month of treatment. Patients in the systemic retinoid (isotretinoin) group will have their lipids evaluated after 1 and 4-5 months of treatment.
Time frame: at 1 month and 4-5 months of treatment
This study is completed, as verified in May 2017. You cannot join it, but the record below documents what was studied.
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University of California, Davis