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CompletedNCT02120703Updated Apr 23, 2014

Pregabalin Compared to Gabapentin for Pain Control in Lumbar Disc Surgery

A Phase 3 interventional study of Pregabalin and Gabapentin in Intervertebral Disc Prolapse, sponsored by Aga Khan University. Completed at 1 site in Pakistan. Open to participants aged 30 Years to 60 Years. Per ClinicalTrials.gov, last updated 2014-04-23.

Sponsored by Aga Khan University · Phase 3, Interventional, and Supportive care

Phase
Phase 3
Study type
Interventional
Enrollment
78
Allocation
Randomized
Ages
30 Years to 60 Years
Sex
All
01

Study summary

Pregabalin is claimed to have superior analgesic effect at lower doses and better pharmacological profile as compared to gabapentin esp. in perioperative pain control after major surgeries like intervertebral disc surgery.

The investigators found that pregabalin is equivalent to gabapentin for relief of post-operative pain at a lower dose in patients undergoing intervertebral disc surgery.

02

Conditions studied

  • Intervertebral Disc Prolapse

Keywords

  • Pregabalin
  • gabapentin
  • microdiscectomy
  • pain
03

In context

Intervertebral Disc Displacement

478 studies on the registry are indexed under Intervertebral Disc Displacement; 104 are open to participants now.

This study's enrollment of 78 is above the median of 63 across 344 interventional studies indexed under Intervertebral Disc Displacement.

Browse Intervertebral Disc Displacement studies →

Lead sponsor

Aga Khan University is the lead sponsor of 290 studies on the registry; 44 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • 30-60 years age
  • Any gender
  • elective micro discectomy for intervertebral disc prolapse

Exclusion criteria

Exclusion Criteria:

  1. micro discectomy at two or more vertebral levels,
  2. Instrumentation i.e. pedicle screw fixation, hooks etc.,
  3. history of steroids or alcohol use,
  4. Multiple co-morbids i.e. renal failure, chronic liver disease,
  5. use of anticonvulsant drugs,
  6. Spinal deformity,
  7. Obesity (BMI >30), 8) inability to understand and respond VAS and
  1. patients with known allergy to GABA analogues.
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Study design

Phase
Phase 3
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
78 participants (actual)

Study arms

  • Active comparator
    gabapentin

    Drug: Gabapentin

  • Active comparator
    Pregabalin

    Drug: Pregabalin

Interventions

  • DrugPregabalin

    Pregablin 75 mg per oral two times a day

  • DrugGabapentin

    Gabapentin 200 mg twice daily per oral

06

What researchers measure

Primary outcomes

  1. Pain

    Pain measurement using Visual Analogue Score at 24 hours and 7th day of surgery

    Time frame: 7 days

07

Study locations

1 site
  • The Aga Khan University Hospital
    Karachi, Sind 75300, Pakistan
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 23, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT02120703
Lead sponsor
Aga Khan University
Responsible party
Ghulam Murtaza (Dr., Aga Khan University) — Principal investigator
First posted
Apr 23, 2014
Start date
Feb 2011
Primary completion
Oct 2011
Completion
Oct 2011
Last update
Apr 23, 2014

Study contacts

Mohsin Qadeer, FCPS
principal investigator · The Aga Khan University Hospital, Karachi, Pakistan

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2014. You cannot join it, but the record below documents what was studied.

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