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CompletedNCT02098668PAEONUpdated Sep 7, 2016

Mathematical Model for the Human Menstrual Cycle, Endocrinological Diseases and Fertility Treatment-PAEON

An observational study in Polycystic Ovary Syndrome, Endometriosis and Hyperprolactinemia, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to female participants aged 18 Months to 43 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-09-07.

Sponsored by University of Zurich · Observational

Study type
Observational
Time perspective
Prospective
Enrollment
123
Ages
18 Months to 43 Years
Sex
Female
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Study summary

Development of a bio-mathematical model of the human female cycle

Read the detailed description

From hormonal measurements throughout 1-2 menstrual cycles in women with and without endocrinological pathology a mathematical model of the human menstrual cycle will be generated. The model will serve to predict development of the cycle including ovulation as well as to better understand the pathophysiology of endocrinological disorder. In a second step current treatment protocols for fertility treatment will be integrated into the model in order to optimize treatment outcome.

02

Conditions studied

  • Polycystic Ovary Syndrome
  • Endometriosis
  • Hyperprolactinemia

Keywords

  • menstrual cycle dynamics
  • PCOS
  • hyperprolactinemia
  • endometriosis
  • infertility
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In context

Polycystic Ovary Syndrome

956 studies on the registry are indexed under Polycystic Ovary Syndrome; 176 are open to participants now.

This study's enrollment of 123 is close to the median of 118 across 223 observational studies indexed under Polycystic Ovary Syndrome.

Browse Polycystic Ovary Syndrome studies →

Lead sponsor

University of Zurich is the lead sponsor of 1,049 studies on the registry; 133 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Months to 43 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Women with normal and distrubed menstrual cycles Women receiving fertility treatment

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Women during their reproductive phase, no hormonal therapy

Exclusion criteria

Exclusion criteria:

  • Amenorrhoae
05

Study design

Time perspective
Prospective
Enrollment
123 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Normal, pathological cycle, infertility

    healthy women PCOS Endometriosis hyperprolactinemia fertility treatment

    Other: Fertility treatment

Interventions

  • OtherFertility treatment

    Fertility treatment

06

What researchers measure

Primary outcomes

  1. Hormonal parameters

    Development of a mathematical model of the menstrual cycle

    Time frame: 3 years

Secondary outcomes

  1. Dynamics of fertility treatment

    Mathematical model to improve fertility treatments

    Time frame: 2 years

Other outcomes

  1. Dynamics of gyneco-endocrinological diseases

    To better understand the pathophysiological mechanisms in endocrinological diseases

    Time frame: 3 years

07

Study locations

1 site
  • University Hospital Zurich, Division of Reproductive Endocrinology
    Zurich, ZH 8091, Switzerland
08

References and documents

Publications

  • Leeners B, Kruger THC, Geraedts K, Tronci E, Mancini T, Egli M, Roblitz S, Saleh L, Spanaus K, Schippert C, Zhang Y, Ille F. Associations Between Natural Physiological and Supraphysiological Estradiol Levels and Stress Perception. Front Psychol. 2019 Jun 11;10:1296. doi: 10.3389/fpsyg.2019.01296. eCollection 2019. PubMed 31244718 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 7, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02098668
Responsible party
Sponsor
First posted
Mar 28, 2014
Start date
Sep 2013
Primary completion
Feb 2016
Completion
Apr 2016
Last update
Sep 7, 2016

Study contacts

Brigitte Leeners, MD
principal investigator · University Hospital Zurich, Division of Reproductive Endocrinology

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2016. You cannot join it, but the record below documents what was studied.

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