Nitrate Supplementation in Chronic Obstructive Pulmonary Disease (COPD)

Browse trials for

• Lung Diseases 3,303
• Lung Diseases, Obstructive 2,592
• Pulmonary Disease, Chronic Obstructive 4,131

Keywords

• COPD
• nitrate supplementation
• metabolic efficiency

Lung Diseases

3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.

This study's enrollment of 20 is below the median of 72 across 2,118 interventional studies indexed under Lung Diseases.

Lead sponsor

Maastricht University Medical Center is the lead sponsor of 835 studies on the registry; 122 are open to participants now.

Study arms

• Active comparator
  Nitrate supplementation

  Sodium nitrate solution

  Dietary Supplement: Nitrate supplementation · Dietary Supplement: Placebo supplementation

• Placebo comparator
  Placebo supplementation

  Sodium chloride solution

  Dietary Supplement: Nitrate supplementation · Dietary Supplement: Placebo supplementation

Interventions

• Dietary supplementNitrate supplementation

  7 days of supplementation with sodium nitrate solution

• Dietary supplementPlacebo supplementation

  7 days of supplementation with sodium chloride solution

Primary outcomes

1. Change in metabolic efficiency during exercise

   Metabolic efficiency (degree of efficiently used energy during exercise) will be assessed during the test days before and after the two supplementation periods (active and placebo) for a total timespan of 3 weeks.

   Time frame: Baseline, day 7, day 14 and day 21.

Secondary outcomes

1. Change in blood pressure during exercise

   Change in blood pressure will be assessed during the test days before and after the two supplementation periods (active and placebo) for a total timespan of 3 weeks.

   Time frame: Baseline, day 7, day 14 and day 21.

2. Change in dyspnea during exercise

   Change in dyspnea will be assessed during the test days before and after the two supplementation periods (active and placebo) for a total timespan of 3 weeks.

   Time frame: Baseline, day 7, day 14 and day 21.

3. Change in cycle endurance time during exercise.

   Change in cycle endurance time will be assessed during the test days before and after the two supplementation periods (active and placebo) for a total timespan of 3 weeks.

   Time frame: Baseline, day 7, day 14 and day 21.

4. Change in oxygen uptake (VO2 mL/min) during exercise

   Change in oxygen uptake will be assessed during the test days before and after the two supplementation periods (active and placebo) for a total timespan of 3 weeks.

   Time frame: Baseline, day 7, day 14 and day 21

5. Change in Resting Energy Expenditure (REE)

   Change in REE will be assessed during the test days before and after the two supplementation periods (active and placebo) for a total timespan of 3 weeks.

   Time frame: Baseline, day 7, day 14 and day 21

6. Change in plasma concentrations of nitrate and nitrite, glucose, insulin, lactate and free fatty acids, IFABP and cardiac troponin

   Change in these plasma concentrations will be assessed during the test days before and after the two supplementation periods (active and placebo) for a total timespan of 3 weeks.

   Time frame: Baseline, day 7, day 14 and day 21

Other outcomes

1. VO2max and Wmax

   Time frame: Baseline

2. height, body weight and body mass index (BMI)

   Time frame: Baseline

3. Fat free mass and fat mass

   Fat free mass and fat mass determined by DEXA-scan

   Time frame: Baseline

4. Lung function

   Time frame: Baseline

5. Physical activity

   Time frame: During the two supplementation periods