A Phase 4 interventional study of Fentanyl and Remifentanil in Delirium, sponsored by Peking University People's Hospital. Status unknown. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2014-07-16.
Sponsored by Peking University People's Hospital · Phase 4, Interventional, and Prevention
Benzodiazepines is a commonly uesd sedative medication,there are many reports that Benzodiazepines is associated with delirium ,but using of analgesia reduces benzodiazepines requirements .The purpose of this study is to determine whether analgesia based sedation protocol reduces the incident of delirium.
1,071 studies on the registry are indexed under Delirium; 239 are open to participants now.
This study's planned enrollment of 100 is below the median of 119 across 608 interventional studies indexed under Delirium.
Browse Delirium studies →Peking University People's Hospital is the lead sponsor of 603 studies on the registry; 241 are open to participants now.
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Remifentanil 1µg/kg/hr intravenous pump and Midazolam loading dose 0.05mg/kg followed by 0.02\~0.1mg/kg/h continuous intravenous pump for 7days or extubation
Drug: Remifentanil
Fentanyl 1µg/kg/hr intravenous pump and Midazolam loading dose 0.05mg/kg followed by 0.02\~0.1mg/kg/h continuous intravenous pump for 7days or extubation
Drug: Fentanyl
Normal saline1µg/kg/hr intravenous pump and Midazolam loading dose 0.05mg/kg followed by 0.02\~0.1mg/kg/h continuous intravenous pump for 7days or extubation
Drug: Normal saline
The incidence and duration of delirium in patients with different regimens
Time frame: 1 day
Mortality
Time frame: 28 days
Ventilator-free days
Time frame: an expected average of 7 days
Mean days of mechanical ventilation
Time frame: an expected average of 7 days
Length of ICU stay
Time frame: an expected average of 7 days
Index of anesthesia depth monitoring
Analgesic level、sedation level、brain function、 blood perfusion for peripheral and brain circulation、sleep stages and variation of blood volume
Time frame: From admission to ICU to weaning,about 7 days
Infusion velocity and total dose of sedative drugs in different groups
Time frame: From admission to ICU to extubation or drug withdrawal,about 7 days
Plasma melatonin level
Time frame: Every 6 hours during the next ICU day
Total rescue dose of midazolam
Time frame: Seven days after giving midazolam to patient
Variations of HR、RR、BP、SpO2
Time frame: an expected average of 7 days
No study locations are listed for this record.
This study is status unknown, as verified in Jul 2014. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Fentanyl · Remifentanil
Peking University People's Hospital →