An interventional study of Attention Training Program in Obsessive-Compulsive Disorder, sponsored by Humboldt-Universität zu Berlin. Completed at 1 site in Germany. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2014-11-13.
Sponsored by Humboldt-Universität zu Berlin · Not applicable, Interventional, and Treatment
The goal of this study is to investigate an attention training program for participants with Obsessive-Compulsive Disorder. The attention training consists of a modified dot probe task with picture stimuli related to washing and checking paired with neutral pictures.
Participants are randomly assigned to an experimental and a placebo-control group. After a minimum of 4 weeks of attention training we expect to find differences between participants of the experimental and the control group in terms of attention bias, OCD symptoms, anxiety and depression.
367 studies on the registry are indexed under Compulsive Personality Disorder; 67 are open to participants now.
This study's enrollment of 108 is above the median of 37 across 306 interventional studies indexed under Compulsive Personality Disorder.
Browse Compulsive Personality Disorder studies →Humboldt-Universität zu Berlin is the lead sponsor of 3 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Current treatment is not an exclusion criterion, but data on treatment status (current psycho- or pharmacotherapy for OCD) will enter our statistical analyses.
Same procedure, stimulus material, frequency and duration as in experimental group. The only difference: In the placebo group the probe randomly appears at one of the two locations on the screen so as not to train attention in any direction. Thus, the placebo training sessions are identical to the bias assessment sessions.
The Attention Training consists of a modified dot-probe task. In this task pairs of pictures (OCD-relevant/neutral) are presented for 500 ms on a computer screen. Next, a probe appears on one of the two former picture locations. Participants have to react to that probe by pressing the corresponding button on the keyboard. One training session takes approximately 10 minutes in which 160 stimulus pairs are shown. In the experimental group the probe always appears at the location of the neutral picture so as to train attention away from OCD-relevant stimuli. Participants are asked to complete at least 2 training sessions per week over a period of 5 weeks. The first and last session are bias assessment sessions (see outcome measures), but participants stay blind to this.
Behavioral: Attention Training Program
Also known as: ATP, Attention Bias Modification Treatment, ABMT, Bias Modification, Attentional Training
Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T1
The Y-BOCS-SRS measures severity of OCD symptoms.
Time frame: pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set)
Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T2
The Y-BOCS-SRS measures severity of OCD symptoms.
Time frame: post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)
Yale-Brown Obsessive-Compulsive Scale Self-Report Scale (Y-BOCS-SRS) T3
The Y-BOCS-SRS measures severity of OCD symptoms.
Time frame: follow-up, between day 27 and 50 after T2 questionnaires (time limit set)
Obsessive-Compulsive Inventory-Revised (OCI-R) T1
The OCI-R measures severity of OCD symptoms.
Time frame: pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set)
Obsessive-Compulsive Inventory-Revised (OCI-R) T2
The OCI-R measures severity of OCD symptoms.
Time frame: post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)
Obsessive-Compulsive Inventory-Revised (OCI-R) T3
The OCI-R measures severity of OCD symptoms.
Time frame: follow-up, between day 27 and 50 after T2 questionnaires (time limit set)
Beck Anxiety Inventory (BAI) T1
The BAI measures severity of anxiety symptoms.
Time frame: pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set, all further steps relative to exact time point of T1 questionnaires)
Beck Anxiety Inventory (BAI) T2
The BAI measures severity of anxiety symptoms.
Time frame: post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)
Beck Anxiety Inventory (BAI) T3
The BAI measures severity of anxiety symptoms.
Time frame: follow-up, between day 27 and 50 after T2 questionnaires (time limit set)
Beck Depression Inventory II (BDI-II) T1
The BDI measures severity of depressive symptoms.
Time frame: pre-treatment, estimated: between day 1 and day 7 after enrolment (no time limit set, all further steps relative to exact time point of T1 questionnaires)
Beck Depression Inventory II (BDI-II) T2
The BDI measures severity of depressive symptoms.
Time frame: post-treatment, between day 1 and 6 after T2 Bias Assessment (time limit set)
Beck Depression Inventory II (BDI-II) T3
The BDI measures severity of depressive symptoms.
Time frame: follow-up, between day 27 and 50 after T2 questionnaires (time limit set)
Attention bias towards OCD-relevant stimuli at T1 measured with a dot-probe task.
Attention bias is measured using a dot-probe task. In this task pairs of pictures (OCD-relevant/neutral) are presented briefly on a computer screen. Next, a probe randomly appears on one of the two former picture locations. Participants have to react to that probe by pressing the corresponding button on the keyboard. Attention bias is calculated as the mean difference in reaction times between trials in which the probe appears at the OCD-relevant location vs. trials in which it appears at the neutral location. The bias assessment session is masked as first training sessions in both groups.
Time frame: after T1 questionnaires and pre-treatment, estimated: between day 1 and 3 after T1 questionnaires (no time limit set)
Attention bias towards OCD-relevant stimuli at T2 measured with a dot-probe task.
Attention bias is measured using a dot-probe task. In this task pairs of pictures (OCD-relevant/neutral) are presented briefly on a computer screen. Next, a probe randomly appears on one of the two former picture locations. Participants have to react to that probe by pressing the corresponding button on the keyboard. Attention bias is calculated as the mean difference in reaction times between trials in which the probe appears at the OCD-relevant location vs. trials in which it appears at the neutral location.
Time frame: post-treatment, after a minimum of 8 training sessions over a time of 4 weeks, estimated: between day 1 and 4 after last training session (no time limit set)
This study is completed, as verified in Nov 2014. You cannot join it, but the record below documents what was studied.
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Humboldt-Universität zu Berlin