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CompletedNCT01962038Updated Apr 5, 2018

A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment

An interventional study of Combined Aerobic and Resistance Exercise and Stretching Exercises in Amnestic Mild Cognitive Impairment, sponsored by Palo Alto Veterans Institute for Research. Completed at 1 site in United States. Open to participants aged 50 Years to 90 Years. Per ClinicalTrials.gov, last updated 2018-04-05.

Sponsored by Palo Alto Veterans Institute for Research · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
72
Allocation
Randomized
Ages
50 Years to 90 Years
Sex
All
01

Study summary

The purpose of this study is examine the efficacy of a combination physical exercise and cognitive training program on improving memory in older Veterans with amnestic Mild Cognitive Impairment.

02

Conditions studied

  • Amnestic Mild Cognitive Impairment

Keywords

  • Mild Cognitive Impairment
  • Aging
03

In context

Cognitive Dysfunction

3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.

This study's enrollment of 72 is above the median of 65 across 2,808 interventional studies indexed under Cognitive Dysfunction.

Browse Cognitive Dysfunction studies →

Lead sponsor

Palo Alto Veterans Institute for Research is the lead sponsor of 51 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • diagnosis of amnestic Mild Cognitive Impairment
  • available informant
  • visual and auditory acuity to allow neuropsychological testing
  • willingness to participate in exercise training + cognitive training for 8 months
  • approval of primary provider to participate in exercise trial

Exclusion criteria

Exclusion Criteria:

  • current severe psychiatric disorder
  • diagnosis of dementia
  • history of neurological or system illness affecting CNS function
  • acute illness or unstable chronic illness
  • current severe cardiac disease
  • inability to exercise consistently because of orthopedic or musculoskeletal problems
  • morbid obesity
  • inability to read, verbalize understanding and voluntarily sign the informed consent
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
72 participants (actual)

Study arms

  • Active comparator
    Combined Aerobic and Resistance Exercise/Cognitive Training

    Behavioral: Combined Aerobic and Resistance Exercise · Behavioral: Cognitive Training

  • Active comparator
    Stretching Exercises/Cognitive Training

    Behavioral: Stretching Exercises · Behavioral: Cognitive Training

Interventions

  • BehavioralCombined Aerobic and Resistance Exercise

    Gym and home based aerobic and resistance exercises

  • BehavioralStretching Exercises

    Gym and home based stretching exercises

  • BehavioralCognitive Training

    Group-based cognitive training

06

What researchers measure

Primary outcomes

  1. Change from Baseline to 28 weeks in delayed recall of a word list

    Time frame: Baseline, 24 weeks, 28 weeks

  2. Change from Baseline to 28 weeks in Delayed Recall of Names-Face Task

    Time frame: Baseline, 24 weeks, 28 weeks

Secondary outcomes

  1. Non-Cognitive Outcomes (Depression, Sleep, Quality of Life)

    Time frame: Baseline, Time 2, Time 3

Other outcomes

  1. Exercise Assessment

    Time frame: Baseline, Time 2, and Time 3

07

Study locations

1 site
  • VA Palo Alto Health Care System
    Palo Alto, California 94304, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 5, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01962038
Lead sponsor
Palo Alto Veterans Institute for Research
Collaborators
U.S. Army Medical Research and Development Command
Responsible party
J. Kaci Fairchild, PhD (Clinical Psychologist, Palo Alto Veterans Institute for Research) — Principal investigator
First posted
Oct 14, 2013
Start date
May 2013
Primary completion
Jul 2017
Completion
Nov 2017
Last update
Apr 5, 2018

Study contacts

Jennifer K Fairchild, PhD
principal investigator · VA Palo Alto Health Care System

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2018. You cannot join it, but the record below documents what was studied.

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