An observational study in Neurological Diseases or Conditions, Fluid Responsiveness and Non Invasive Cardiac Output Monitoring, sponsored by Samsung Medical Center. Withdrawn at 1 site in Korea, Republic of. Open to participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2016-05-27.
Sponsored by Samsung Medical Center · Observational
Optimal fluid management has been considered as crucial part to determine postoperative outcome and organ function. Recently developed, non invasive cardiac output measurement(NICOM, Cheetah Medical, Portland, OR)has enabled continuous cardiac output(CO) monitoring just by attaching electrode on chest wall. Moreover, CO and SSV derived from NICOM have been demonstrated as predictors of fluid responsiveness. Therefore, the aim of this study is to evaluate stroke volume variation derived from NICOM as a predictor of fluid responsiveness in neurosurgical patients. In addition, we plan to reveal inconclusive patients using gray zone approach.
Optimal fluid management has been considered as crucial part to determine postoperative outcome and organ function. Many reports have focussed on evaluation of fluid responsiveness using various parameters such as pulse pressure variation (PPV) or stroke volume variation (SSV) derived from invasive or semi-invasive monitoring. Recently developed, non invasive cardiac output measurement(NICOM, Cheetah Medical, Portland, OR)has enabled continuous cardiac output(CO) monitoring just by attaching electrode on thorax. Moreover, CO and SSV derived from NICOM have been demonstrated as predictors of fluid responsiveness. Therefore, the aim of this study is to evaluate stroke volume variation derived from NICOM as a predictor of fluid responsiveness in neurosurgical patients. In addition, we plan to reveal inconclusive patients using gray zone approach.
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Patients undergoing neurosurgery under general anesthesia in supine position
Exclusion Criteria:
All enrolled patients
Other: 500ml fluid loading
Fluid loading to evaluate fluid responsiveness
Also known as: 500ml loading of crystalloid(Plasma Solution-A Injection CJ) over 15min, at the end of operation, when the main procedure finished and there is no strong, stimulation with stable hemodynamics
Stroke volume variation
5min following the end of rapid fluid infusion: 5 min after the end of fluid loading
Time frame: 5min following the end of rapid fluid infusion
Correlation with pulse pressure variation
5min following the end of rapid fluid infusion: 5 min after the end of fluid loading
Time frame: 5 min following the end of rapid fluid infusion
TPR(total peripheral resistance), TPRI(total peripheral resistance index)
5min following the end of rapid fluid infusion: 5 min after the end of fluid loading
Time frame: 5min following the end of rapid fluid infusion
This study is withdrawn, as verified in May 2016. You cannot join it, but the record below documents what was studied.
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Samsung Medical Center