An observational study in Normal Pregnancies, sponsored by Meir Medical Center. Status unknown at 1 site in Israel. Per ClinicalTrials.gov, last updated 2013-06-21.
Sponsored by Meir Medical Center · Observational
Genetic and environmental factors are believed to play a major role in intrauterine growth and intrauterine programming. We intend to study genetic factors such as Telomere homeostasis, senescence, genomic instability and the presence of Genomic copy number variations in placental tissue from pregnancies complicated with Intrauterine growth restriction(IUGR), Gestational and pre gestational Diabetes, placentas from IVF pregnancies and from normal pregnancies. We also intend to assess these factors in cord blood and maternal blood.
Based on the previous data from our group as well as other laboratories, we postulate that there is a correlation between impaired telomere homeostasis, senescence genomic instability and intra-uterine programming in placentas and in fetuses exposed to suboptimal intrauterine conditions such as hypoxia or hyperglycemia. Improved understanding of the mechanisms that produce the genomic changes in IUGR placentas and their influence on later risks of developing the metabolic syndrome should provide basis for future research that might lead into improved outcome of IUGR fetuses.
1,964 studies on the registry are indexed under Metabolic Syndrome; 330 are open to participants now.
This study's planned enrollment of 160 is below the median of 200 across 458 observational studies indexed under Metabolic Syndrome.
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Samples from pregnancies complicated with IUGR, Gestational and pre gestational Diabetes, placentas from IVF pregnancies and from normal pregnancies. We intend to assess these factors in placental tissue, in cord blood and maternal blood.
Exclusion Criteria:
Pregnancies complicated with IUGR. Fetal growth beneath the 10th percentile
Normal glucose levels before 20 weeks, and positive Oral glucose tolerance test
A diagnosis of Diabetes before pregnancy or elevated glucose levels before 20 weeks.
Rate of Copy Number Variations
Time frame: 10 yeras
Telomere length
Time frame: 10 years
Number of copies of mitochondrial DNA
Time frame: 10 years
This study is status unknown, as verified in Jun 2013. You cannot join it, but the record below documents what was studied.
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Meir Medical Center