A Phase 4 interventional study of Hypoxic ventilatory response and Hypercapnic ventilatory response in Hypoxia, Anesthetics and Conscious Sedation, sponsored by Karolinska University Hospital. Completed at 1 site in Sweden. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-02-26.
Sponsored by Karolinska University Hospital · Phase 4, Interventional, and Basic science
The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.
15 volunteers will be investigated for their hypoxic and hypercapnic ventilatory response during sedation with dexmedetomidine and propofol in a randomized cross-over study.
6 volunteers will be investigated for their repeated response to hypoxia and hypercapnia in order to validate the method.
1,231 studies on the registry are indexed under Hypoxia; 241 are open to participants now.
This study's enrollment of 11 is below the median of 45 across 853 interventional studies indexed under Hypoxia.
Browse Hypoxia studies →Karolinska University Hospital is the lead sponsor of 275 studies on the registry; 54 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Snoring
Sedation with dexmedetomidine
Procedure: Hypoxic ventilatory response · Procedure: Hypercapnic ventilatory response
Sedation with propofol
Procedure: Hypoxic ventilatory response · Procedure: Hypercapnic ventilatory response
Also known as: HVR
Also known as: HCVR
Hypoxic ventilatory response
Acute hypoxic ventilatory response,i.e. the ventilatory response to acute hypoxia measured as change in minute ventilation over change in peripheral oxygen saturation
Time frame: One day for each drug; before,during and after sedation with dexmeditomidine or propofol
hypercapnic ventilatory response
The acute ventilatory response to hypercapnia, i.e. change in minute ventilation over change in end-tidal carbon dioxide
Time frame: One day for each drug; Before, during and after sedation with dexmedetomidine or propofol
upper airway obstruction
Objective signs of upper airway obstruction, e.g. Interruption of airflow at the same time as breathing movements of the thoracic wall, paradoxal breathing, increased airway resistance
Time frame: One day for each drug: Before, during and after sedation with dexmedetomidine or propofol
Plasma concentration
Plasma concentration of dexmedetomidine or propofol
Time frame: One day for each drug; At target sedation
Sedation level
Sedation level will be measured as Richmond Agitation Sedation Scale(RASS) the observer's assessment of alertness/sedation scale (OAA/S)
Time frame: One day; During the whole experimental procedure
Bispectral index
Bispectral index (BIS) gives a number between 0-100
Time frame: One day; During the whole experimental procedure
This study is completed, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.
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Karolinska University Hospital