A Phase 4 interventional study of Anti-Infective Agents in Asymptomatic Bacteriuria, Bacteriuria and Urinary Tract Infections, sponsored by Erasme University Hospital. Completed at 15 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-07-18.
Sponsored by Erasme University Hospital · Phase 4, Interventional, and Treatment
The purpose of this study is to compare antibiotics versus no-treatment in kidney transplant recipients with asymptomatic bacteriuria.
The BiRT trial investigators would be interested to collaborate with some additional hospitals, particularly centers having high level of antimicrobial resistance.
51 studies on the registry are indexed under Bacteriuria; 3 are open to participants now.
This study's planned enrollment of 198 is above the median of 100 across 37 interventional studies indexed under Bacteriuria.
Browse Bacteriuria studies →Erasme University Hospital is the lead sponsor of 181 studies on the registry; 35 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
10 days of antibiotics, started and selected according to the antibiogram results. In case of reinfection or relapse, re-administration of antimicrobial agents will be performed according to the antibiogram results (for a maximum of 3 cycles of ten days of antibiotics during the 12 months of the follow-up).
Other: Anti-Infective Agents
no antibiotics delivered in case of asymptomatic bacteriuria, independently of the number of asymptomatic episodes.
10 days of antibiotics, started and selected according to the antibiogram results. In case of reinfection or relapse, re-administration of antimicrobial agents will be performed according to the antibiogram results (for a maximum of 3 cycles of ten days of antibiotics during the 12 months of the follow-up)
Also known as: Anti-Infective Agents: not applicable - no specific agent, The choice of antimicrobial agent is at the discretion of the physician, and is based on the antibiogram results
cumulative incidence of a first episode of symptomatic urinary tract infection
Time frame: 12 months
incidence of a first episode of pyelonephritis
Time frame: 12 months
clearance of asymptomatic bacteriuria
Time frame: 12 months
occurrence of new episodes of asymptomatic bacteriuria
Time frame: 12 months
graft function/graft survival
Time frame: 12 months
incidence of graft rejection
Time frame: 12 months
patient survival
Time frame: 12 months
utility of a control urine culture for diagnosis of asymptomatic bacteriuria in kidney transplant recipients
Time frame: 12 months
level of antimicrobial resistance in bacteria responsible for symptomatic urinary tract infections
Time frame: 12 months
total number of days of antimicrobial therapy
Time frame: 12 months
cost of antimicrobial treatment for asymptomatic bacteriuria and symptomatic urinary tract infection
Time frame: 12 months
number of hospitalizations for asymptomatic bacteriuria and symptomatic urinary tract infection treatment
Time frame: 12 months
total number of symptomatic urinary tract infections in both groups
Time frame: 12 months
Ran from Apr 2014 to primary completion in Jul 2019, 63 months.
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This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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