A Phase 4 interventional study of Cefazolin used in antimicrobial prophylaxis in Obesity, sponsored by Universidade Federal de Pernambuco. Completed at 1 site in Brazil. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2013-05-03.
Sponsored by Universidade Federal de Pernambuco · Phase 4, Interventional, and Treatment
Eighteen patients were given a dose of 2g Cefazolin in anesthetic induction, supplemented with 1g delivered through continuous infusion during surgery. Adipose samples, obtained at the beginning and end of surgery, were analyzed using high performance liquid chromatography.
Some published studies suggest that the dose of 2g does not supply the minimum inhibitory concentration for principal causal agents of surgical site infection.
To determine the concentration of Cefazolin in adipose tissue of patients undergoing bariatric surgery and to evaluate the relationship between concentrations obtained and body mass index (BMI).
6,296 studies on the registry are indexed under Obesity; 1,692 are open to participants now.
This study's enrollment of 18 is below the median of 78 across 4,878 interventional studies indexed under Obesity.
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Cefazolin used in antimicrobial prophylaxis Cefazolin administered a first dose of 2g in anesthetic induction, followed by continuous dosage of 1g diluted in 250mL of saline solution for two hours. Two samples of subcutaneous tissue were collected for analysis: the first soon after the incision, and a second before skin synthesis. The samples were processed by High Pressure Liquid Chromatography (HPLC).
Drug: Cefazolin used in antimicrobial prophylaxis
Cefazolin administered a first dose of 2g in anesthetic induction, followed by continuous dosage of 1g diluted in 250mL of saline solution for two hours. Two samples of subcutaneous tissue were collected for analysis: the first soon after the incision, and a second before skin synthesis. The samples were processed by HPLC.
dosage of Cefazolin in adipose tissue during bariatric surgery
Time frame: eight months
This study is completed, as verified in Apr 2013. You cannot join it, but the record below documents what was studied.
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Universidade Federal de Pernambuco