An interventional study of atDCS and sham tDCS in Residual Aphasia, sponsored by Charite University, Berlin, Germany. Status unknown at 1 site in Germany. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2013-05-03.
Sponsored by Charite University, Berlin, Germany · Not applicable, Interventional, and Basic science
The present study assesses whether language functions in patients with residual post-stroke aphasia can be improved by transcranial direct current stimulation administered to the primary motor cortex in the language dominant (left) hemisphere.
Patients will participate in two tDCS sessions (atDCS; sham) in a cross-over within subjects design. tDCS or placebo will be administered during simulatneous fMRI to assess neural signatures of the stimulation. Order of stimulation will be counterbalanced between subjects
365 studies on the registry are indexed under Aphasia; 89 are open to participants now.
This study's planned enrollment of 16 is below the median of 30 across 316 interventional studies indexed under Aphasia.
Browse Aphasia studies →Charite University, Berlin, Germany is the lead sponsor of 836 studies on the registry; 129 are open to participants now.
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atDCS will be administered for 20 minutes with 1 milliampere (1 mA) to the left primary hand motor cortex
Device: atDCS · Device: sham tDCS
sham tDCS will be administered to the left primary hand motor cortex
Device: atDCS · Device: sham tDCS
atDCS will be delivered with a constant current of 1 mA during simultaneous resting-state (RS) and task-related (picture naming) functional magnetic resonance imaging (fMRI). The current will be turned on prior to the RS-fMRI scan and continues for 20 minutes.
During sham the current will be increeased and decreased in a ramp-like fashion (10 sec)
Response latency during picture naming task (max. 80)
Subjects are assessed in a cross-over design. The primary outcome measure will be assessed twice in each subject, either during placebo ("sham) stimulation or active (anodal) stimulation with transcranial direct current stimulation. Order of stimulation will be counterbalanced across the group.
Time frame: Change in response latency between assessment 1 (week 1) and assessment 2 (week 2), assessments 1 and 2 are seperated by one week
Change in neural activity measured by functional magnetic resonance imaging
Time frame: Change in fMRI activity between Assessment 1 (week 1) and Assessment 2 (week 2), assessments 1 and 2 are seperated by one week
This study is status unknown, as verified in Apr 2013. You cannot join it, but the record below documents what was studied.
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Charite University, Berlin, Germany