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CompletedNCT01843361Bo-CRISPUpdated Apr 30, 2013

Clopidogrel Response in Acute Ischemic Stroke. The Bochumer CRISP Study

An observational study in Ischemic Stroke, sponsored by Ruhr University of Bochum. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2013-04-30.

Sponsored by Ruhr University of Bochum · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
159
Ages
18 Years and older
Sex
All
01

Study summary

The aim of this study was to determine the prevalence rate and risk factors for chemical laboratory clopidogrel low-response (CLR) in the acute phase after an ischemic stroke.

02

Conditions studied

  • Ischemic Stroke

Keywords

  • Stroke
  • Clopidogrel
  • Aggregometry
  • Antiplatelet therapy
  • Platelet function tests
03

In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

This study's enrollment of 159 is close to the median of 160 across 1,692 observational studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

Ruhr University of Bochum is the lead sponsor of 124 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with an acute ischemic stroke admitted to our stroke unit and treated with clopidogrel

Inclusion criteria

  • acute ischemic stroke
  • admittance to stroke unit
  • clopidogrel medication

Exclusion criteria

Exclusion Criteria:

  • no consent
  • prior bleeding disorders
  • severe liver disorders
  • current gastrointestinal disorders
  • congestive heart failure
  • life-threatening malignancies
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
159 participants (actual)
Patient registry
No

Groups and cohorts

  • acute ischemic stroke

    Determing cardiovascular risk factors or medication on clopidogrel response rates after an acute ischemic stroke

06

What researchers measure

Primary outcomes

  1. Result of platelet function test

    Aggregometry result of antiplatelet therapy

    Time frame: one day

07

Study locations

1 site
  • Department of Neurology, Ruhr University Bochum
    Bochum, 44791, Germany
08

References and documents

Publications

  • Meves SH, Overbeck U, Endres HG, Krogias C, Neubauer H. Dose-dependent effect of early antiplatelet therapy in acute ischaemic stroke. Thromb Haemost. 2012 Jan;107(1):69-79. doi: 10.1160/TH11-06-0436. Epub 2011 Dec 8. PubMed 22159509 ↗
  • Fong J, Cheng-Ching E, Hussain MS, Katzan I, Gupta R. Predictors of biochemical aspirin and clopidogrel resistance in patients with ischemic stroke. J Stroke Cerebrovasc Dis. 2011 May-Jun;20(3):227-30. doi: 10.1016/j.jstrokecerebrovasdis.2009.12.004. Epub 2010 Jul 10. PubMed 20621513 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 30, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01843361
Lead sponsor
Ruhr University of Bochum
Responsible party
Saskia Meves (MD, Ruhr University of Bochum) — Principal investigator
First posted
Apr 30, 2013
Start date
Jul 2010
Primary completion
Dec 2012
Completion
Dec 2012
Last update
Apr 30, 2013

Study contacts

Saskia H Meves, MD
principal investigator · Ruhr University Bochum, Department of Neurology

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2013. You cannot join it, but the record below documents what was studied.

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