An interventional study of The IPS-MA method in Affective Disorder, Major Depressive Disorder and Bipolar Disorder, sponsored by Amager Hospital. Completed at 1 site in Denmark. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-02-04.
Sponsored by Amager Hospital · Not applicable, Interventional, and Other
The aim of the present study, is to evaluate the effect of a supported employment intervention, IPS-modified for people with mood and anxiety (IPS-MA) on employment or education, when offered to people with onset mood or anxiety disorders who are not likely to be able to return to work within three month.
The hypothesis is that the IPS-MA method is associated with a shorter recovery period and more people returning to work or education, compared to treatment as usual.
Background: The IPS-MA method is a modified Individual Placement and Support (IPS) intervention, aiming at supporting people with mood or anxiety disorders regain their workability and return to work or education. Previous studies have showed, that IPS has an effect on employment when offered to people with severe mental illness. Further studies are crucial to demonstrate whether the modified IPS, the IPS-MA method, has an effect when offered to people with mood or anxiety disorders who are not yet chronified.
Methods/design:The trial design is a randomized, assessor-blinded, clinical trial of the IPS-MA method in addition to treatment as usual compared to treatment as usual alone for 326 participants diagnosed with a mood or anxiety disorder, living in the Capital Region of Denmark. The primary outcome is competitive employment or education. Secondary outcomes are days of competitive employment or education, disease symptoms, level of functioning, and quality of life at follow-up 12 and 24 months after baseline.
561 studies on the registry are indexed under Mood Disorders; 105 are open to participants now.
This study's enrollment of 326 is above the median of 80 across 419 interventional studies indexed under Mood Disorders.
Browse Mood Disorders studies →Amager Hospital is the lead sponsor of 21 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The IPS-MA method consists of five basic services for the participants. 1)Individual mentor support, based on psychiatric knowledge. 2)Coordination by the mentor of activities, internal as well as from external providers. 3)Career counseling aimed at people with mental illnesses. 4)Impartial help to clarify private economy. 5) Contact to employers to help participants obtain jobs, and keep them. Participants will receive the IPS-MA method in addition to treatment as usual.
Behavioral: The IPS-MA method
Participants randomised to the control group will receive "treatment as usual" only. This means the standard support offered by the social- and health services in Denmark.
During the first 6 months participants are usually offered 3 meetings with their mentor per month, lasting approximately 1 1/2 hours each. The following 6 months they are offered 1 meeting per month, lasting approximately 1 hour. The estimated duration of the IPS-MA intervention is 12 months, but since the needs of the participants are very individual, this may vary.
Also known as: IPS-modified for people recently diagnosed with mood or anxiety disorders (IPS-MA)
Competitive employment or education
Competitive employment includes being on rehabilitation benefits, flexible jobs and wage subsidy job. Information on employment and education will be extracted from the DREAM database. This database is administered by The National Labour Market Authority and contains information on employment, sickness leave, educations eligible to state education grant, pre-vocational training, disability pension, social security, and sickness benefits.
Time frame: 24 months
Number of days of competitive employment or studying
Information will be obtained from the Dream database.
Time frame: 24 months
Hamilton Rating Scale for Depression - 6 items
Level of symptoms of depression
Time frame: 24 months
Hamilton Rating Scale for anxiety -6 item scale
Level of symptoms of anxiety
Time frame: 24 months
Global Assessment of Function (GAF-F)
Level of function
Time frame: 24 months
WHO-5 well-being index
Level of health-related quality of life
Time frame: 24 months
Competitive employment or studying
Competitive employment includes being on rehabilitation benefits, flexible jobs and wage subsidy jobs. Information on employment and education will be extracted from the DREAM database. The database is administered by The National Labour Market Authority and contains information on employment, sickness leave, educations eligible to state education grant, pre-vocational training, disability pension, social security, and sickness benefits.
Time frame: 12 months
Changing from matchgroup 2 or 3 to matchgroup 1
If participants are matchgroup 2 or 3, they are not able to go back to work within the following 3 months. If participants are matchgroup 1, they should be actively seeking jobs.
Time frame: 12 and 24 months
Number of days of competitive employment or studying
Information will be obtained from the Dream database.
Time frame: 12 and 24 months
Time until returning to employment or education
Information will be obtained from the Dream database.
Time frame: 24 months
Hamilton Rating Scale for Depression - 6 items
Level of symptoms of depression
Time frame: 12 months
Hamilton Rating Scale for anxiety -6 item scale
Level of symptoms of anxiety
Time frame: 12 months
The Bech-Rafaelsen Mania Scale (MAS)
Level of symptoms af mania
Time frame: 12 and 24 months
Global Assessment of Function (GAF-F)
Level of function
Time frame: 12 months
Personal and Social Performance (PSP)
Social performance in four domains (socailly usefull activities, personal and social relationships, self-care and disturbing and aggressive behaviour)
Time frame: 12 and 24 months
WHO-5 well-being index
Level of health-related quality of life
Time frame: 12 months
Sheehan Disability Scale (SDS)
Level of function regarding social relationships, work, spare time and family.
Time frame: 12 and 24 months
The Empowerment Scale
Time frame: 12 and 24 months
The Changes Questionnaire
Motivation to seeking employment or education
Time frame: 12 and 24 months
The Client Satisfaction Questionnaire
Satisfaction with treatment
Time frame: 12 and 24 months
Plan to share: No
This study is completed, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Amager Hospital