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CompletedNCT01708681LeSIPUpdated Oct 6, 2015

Lean Seafood Intake and Postprandial Metabolism

An interventional study of Lean seafood and Meat, egg, milk in Hyperlipidemias, Nutritional and Metabolic Diseases and Nutrition Disorders, sponsored by National Institute of Nutrition and Seafood Research, Norway. Completed at 1 site in Norway. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-10-06.

Sponsored by National Institute of Nutrition and Seafood Research, Norway · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
27
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Despite numerous studies of meal components in humans, little is still known about how different meals influence on metabolism. The purpose of this study is to a gain knowledge of how a balanced test meal with either lean seafood (example:cod) or meat as the main protein source will:

  1. affect the postprandial metabolism acutely (test-meal at beginning of the study)
  2. affect the postprandial metabolism after 4 weeks controlled intervention (test meal at end of intervention period)
  3. affect gut microbiota composition
02

Conditions studied

  • Hyperlipidemias
  • Nutritional and Metabolic Diseases
  • Nutrition Disorders
  • Metabolic Diseases
  • Glucose Metabolism Disorders

Keywords

  • Seafood
  • Meat
  • Egg
  • Milk
  • Postprandial lipid metabolism
  • Postprandial glucose metabolism
  • Triglycerides
  • Cholesterol
  • Postprandial incretins
  • Postprandial hormones
03

In context

Hyperlipidemias

821 studies on the registry are indexed under Hyperlipidemias; 105 are open to participants now.

This study's enrollment of 27 is below the median of 87 across 691 interventional studies indexed under Hyperlipidemias.

Browse Hyperlipidemias studies →

Lead sponsor

National Institute of Nutrition and Seafood Research, Norway is the lead sponsor of 6 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • 18-65 years of age
  • Caucasian

Exclusion criteria

Exclusion Criteria:

  • Smoking
  • Diabetes
  • Hysterectomy
  • Abnormal bleeding last 6 months
  • Use of medication that affects lipid and glucose metabolism
  • Large (>10%) alteration in body-weight the last 6 months
  • Chronic, metabolic or acute disease or major surgery within last 3 months
  • Dietary incompatibility with calcium supplementation and/ or seafood consumption (allergy, intolerance, dislike)
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single (Investigator)
Enrollment
27 participants (actual)

Study arms

  • Experimental
    Lean seafood

    Cross-over design, half of the subject will receive lean seafood in study period I and the other half in study period II

    Dietary Supplement: Lean seafood · Dietary Supplement: Meat, egg, milk

  • Active comparator
    Meat, egg, milk

    Cross-over design, half of the subject will receive meat, egg, milk in study period I and the other half in study period II

    Dietary Supplement: Lean seafood · Dietary Supplement: Meat, egg, milk

Interventions

  • Dietary supplementLean seafood
  • Dietary supplementMeat, egg, milk
06

What researchers measure

Primary outcomes

  1. Postprandial lipid measurement

    Time frame: Change from baseline at 4 weeks

Secondary outcomes

  1. Postprandial glucose measurement

    Time frame: Change from baseline at 4 weeks

Other outcomes

  1. Postprandial metabolomic measurement

    Time frame: Change from baseline at 4 weeks

  2. Gut microbiota composition

    Time frame: Change from baseline at 4 weeks

07

Study locations

1 site
  • National Institute of Nutrition and Seafood Research
    Bergen, 5005, Norway
08

References and documents

Publications

  • Aadland EK, Graff IE, Lavigne C, Eng O, Paquette M, Holthe A, Mellgren G, Madsen L, Jacques H, Liaset B. Lean Seafood Intake Reduces Postprandial C-peptide and Lactate Concentrations in Healthy Adults in a Randomized Controlled Trial with a Crossover Design. J Nutr. 2016 May;146(5):1027-34. doi: 10.3945/jn.115.229278. Epub 2016 Apr 20. PubMed 27099232 ↗
  • Aadland EK, Lavigne C, Graff IE, Eng O, Paquette M, Holthe A, Mellgren G, Jacques H, Liaset B. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. Am J Clin Nutr. 2015 Sep;102(3):582-92. doi: 10.3945/ajcn.115.112086. Epub 2015 Jul 29. PubMed 26224298 ↗

Related links

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 6, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01708681
Lead sponsor
National Institute of Nutrition and Seafood Research, Norway
Collaborators
The Research Council of Norway
Responsible party
Sponsor
First posted
Oct 17, 2012
Start date
Oct 2012
Primary completion
May 2013
Completion
Sep 2015
Last update
Oct 6, 2015

Study contacts

Bjørn Liaset, Dr
principal investigator · NIFES
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Oct 2015. You cannot join it, but the record below documents what was studied.

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