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CompletedNCT01694290Updated Nov 26, 2018

Chemical Ice Packs for Cooling Hyperthermic Patients

An interventional study of Chemical Cold Pack in Heat Stroke, Heat Exhaustion, sponsored by Stanford University. Completed at 1 site in United States. Open to male participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-11-26.

Sponsored by Stanford University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
8
Allocation
Randomized
Ages
18 Years to 75 Years
Sex
Male
01

Study summary

A common tool to cool people in the pre-hospital setting is the chemical ice pack. These are used by athletic trainers, EMS personnel, ER staff, and people in the prehosoital setting.

The ability of these to cool a person has never been quantified, the efficiency and extent of cooling, as well as location of placement of ice packs is purely anecdotal. The purpose of this study is to determine whether strategically placed chemical ice packs will provide benefit to individuals subjected to heat stress.

02

Conditions studied

  • Heat Stroke, Heat Exhaustion

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03

In context

Heat Stroke

21 studies on the registry are indexed under Heat Stroke; 10 are open to participants now.

This study's enrollment of 8 is below the median of 34 across 13 interventional studies indexed under Heat Stroke.

Browse Heat Stroke studies →

Lead sponsor

Stanford University is the lead sponsor of 2,168 studies on the registry; 431 are open to participants now.

Of its 267 completed or terminated interventional studies of FDA-regulated products, 207 (78%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • young healthy males > 18 years old with no active medical problems and able to run 10 km.

Exclusion criteria

Exclusion Criteria:

  • Active medical problems or inability to exercise for 45 minutes in a heated room.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
8 participants (actual)

Study arms

  • Experimental
    Chemical Ice packs to neck, groin, axillae

    Chemical ice packs will be changed out every 9 minutes

    Other: Chemical Cold Pack

  • Experimental
    Chemical Ice Packs to cheeks, palms, soles

    Chemical Ice packs will be changed out every 9 minutes

    Other: Chemical Cold Pack

  • No intervention
    no chemical ice packs

Interventions

  • OtherChemical Cold Pack
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What researchers measure

Primary outcomes

  1. Core body temperature cooling

    Time frame: 35 minutes

07

Study locations

1 site
  • Stanford University
    Palo Alto, California, United States
08

References and documents

Publications

  • Lissoway JB, Lipman GS, Grahn DA, Cao VH, Shaheen M, Phan S, Weiss EA, Heller HC. Novel application of chemical cold packs for treatment of exercise-induced hyperthermia: a randomized controlled trial. Wilderness Environ Med. 2015 Jun;26(2):173-9. doi: 10.1016/j.wem.2014.11.006. Epub 2015 Mar 12. PubMed 25771030 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 26, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01694290
Responsible party
Grant S Lipman (Clinical Associate Professor of Emergency Medicine, Stanford University) — Principal investigator
First posted
Sep 27, 2012
Start date
Aug 2012
Primary completion
Jul 2013
Completion
Jul 2013
Last update
Nov 26, 2018

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2018. You cannot join it, but the record below documents what was studied.

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