An observational study in Obesity, sponsored by Örebro University, Sweden. Withdrawn at 1 site in Sweden. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2014-11-05.
Sponsored by Örebro University, Sweden · Observational
The purpose with this study is to investigate whether gastric bypass surgery and the following weight reduction impact the tone in esophageal sphincters and the esophageal function.
In a previous study our group used high resolution solid-state manometry to investigate the pressure in the esophagus and esophageal sphincters in obese patients going through laparoscopic bariatric surgery. These studies showed that the barrier pressure between the stomach and esophagus is significantly lower in obese compared to lean patients. In this study the investigators will examine these patients once more, now after weight reduction to see whether the barrier pressure is back to normal compared to lean patients.
The prevalence of obesity has increased dramatically in recent decades. The gastrointestinal changes associated with obesity have clinical significance for the anesthesiologist in the perioperative period. The upper and lower esophageal sphincters (UES and LES) play a central role in preventing regurgitation and aspiration. The barrier pressure, defined as the difference between the LES pressure and the Intragastric pressure is known to be lower in obese patients compared to lean patients. This might result in a higher risk of regurgitation and aspiration of stomach contents in during induction of anesthesia.
Some studies are made on patients before and after bariatric surgery but results are sparse. In this study the investigators will examine 30 patients before and after bariatric surgery. Our group have performed the measurements on patients before surgery and presented the results in another article. Those patients will be asked to take part of another measurement now 12-18 months after surgery.
30 patients will be consecutively asked and enrolled in this study. Measurements will be performed using high-resolution-solid state manometry.
1,766 studies on the registry are indexed under Weight Loss; 277 are open to participants now.
Browse Weight Loss studies →Örebro University, Sweden is the lead sponsor of 84 studies on the registry; 15 are open to participants now.
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The initial measurements were made on a group of male and female patients 18-60 years with BMI > 35, ASA-classification 1-3 planned for laparoscopic bariatric surgery.
Exclusion Criteria:
Procedure: Laparoscopic gastric bypass surgery
Variation in lower esophageal sphincter tone due to bariatric surgery and weight reduction
Time frame: 12-18 months after surgery
This study is withdrawn, as verified in Nov 2014. You cannot join it, but the record below documents what was studied.
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Örebro University, Sweden