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CompletedNCT01661374Updated Dec 10, 2014

The Effect of Humidification on Mucus Rheology

An observational study in Chronic Obstructive Pulmonary Disease(COPD), sponsored by Virginia Commonwealth University. Completed at 1 site in United States. Open to participants aged 40 Years to 90 Years. Per ClinicalTrials.gov, last updated 2014-12-10.

Sponsored by Virginia Commonwealth University · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
18
Ages
40 Years to 90 Years
Sex
All
01

Study summary

In this study the investigators will collect mucus from mechanical ventilated patients and patients with COPD to study the effect of temperature and humidity, on the biophysical properties of the airway mucus. It is hypothesised that changes in inspired gas temperature and humidity (over time) may affect the biophysical properties of the airway mucus and reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.

Read the detailed description

Expectorated sputum samples are collected and used to measure the biophysical properties of mucus secretions. The samples are later exposed to different temperatures and humidity levels during bench experiments.

02

Conditions studied

  • Chronic Obstructive Pulmonary Disease(COPD)
03

In context

Lung Diseases, Obstructive

2,592 studies on the registry are indexed under Lung Diseases, Obstructive; 198 are open to participants now.

This study's enrollment of 18 is below the median of 150 across 639 observational studies indexed under Lung Diseases, Obstructive.

Browse Lung Diseases, Obstructive studies →

Lead sponsor

Virginia Commonwealth University is the lead sponsor of 641 studies on the registry; 82 are open to participants now.

Of its 88 completed or terminated interventional studies of FDA-regulated products, 62 (70%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Primary Care Clinic,ICU, Pulmonary Clinic

Eligibility criteria

Mechanically Ventilated Patients

Inclusion Criteria:

Any Subject Mechanically Ventilated and producing sputum.

Exclusion

  • None

COPD Group

Inclusion Criteria:

  • 40 to 90 years of age suffering from COPD
  • History of mucus production

Exclusion Criteria:

  • None
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
18 participants (actual)
Biospecimen retention
Samples with dna

Groups and cohorts

  • Mechanically Ventilated
  • Chronic obstructive pulmonary disease (COPD).
06

What researchers measure

Primary outcomes

  1. Sputum Collection

    Sputum is collected during pulmonary function test (PFT) to later measure the biophysical properties of sputum.

    Time frame: 10 minutes

07

Study locations

1 site
  • Virginia Commonwealth University
    Richmond, Virginia 23284, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 10, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01661374
Lead sponsor
Virginia Commonwealth University
Collaborators
Fisher and Paykel Healthcare
Responsible party
Sponsor
First posted
Aug 9, 2012
Start date
Jul 2012
Primary completion
Apr 2014
Completion
Apr 2014
Last update
Dec 10, 2014

Study contacts

Bruce K Rubin, MEngr, MD, MBA, FRCPC
principal investigator · Virginia Commonwealth University School of Medicine

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2014. You cannot join it, but the record below documents what was studied.

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