An interventional study of remote ischemic preconditioning (RIPC) in Cardiovascular Disease, sponsored by Radboud University Medical Center. Completed at 1 site in Netherlands. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-08-09.
Sponsored by Radboud University Medical Center · Not applicable, Interventional, and Treatment
Strenuous exercise in apparent healthy individuals increases plasma (high sensitive) troponin levels. The underlying mechanism is not yet elucidated, but could be explained by changes due to a mismatch in oxygen demand and supply that mimic those of ischemia and reperfusion injury. If the mechanism underlying the troponin release during exercise is similar to that of ischemia reperfusion injury (IRI), than it should be susceptible to remote ischemic preconditioning (RIPC) as RIPC is a well validated technique to reduce IRI. To test this hypothesis healthy volunteers underwent a strenuous exercise test with or without preceding RIPC.
5,025 studies on the registry are indexed under Cardiovascular Diseases; 930 are open to participants now.
This study's enrollment of 20 is below the median of 100 across 2,801 interventional studies indexed under Cardiovascular Diseases.
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Of its 6 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Intensive cycling test preceded by a RIPC protocol.
Other: remote ischemic preconditioning (RIPC)
Intensive cycling test not preceded by a RIPC protocol.
RIPC protocol which consist of three 5-min cycles of bilateral forearm ischemia
serum level of high sensitive troponin at several timepoints
serum level of high sensitive troponin in response to intensive exercise test with or without RIPC at several timepoints
Time frame: timepoints t= baseline, 0, 1, 2, 3,4 and 8 hours after finishing exercise
This study is completed, as verified in Aug 2011. You cannot join it, but the record below documents what was studied.
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