A Phase 2 interventional study of Levamisole+cyclosporin A+Glucocorticoids and cyclosporin A+Glucocorticoids in Paroxysmal Nocturnal Hemoglobinuria, Hemoglobinuria and Hemoglobinuria, Paroxysmal, sponsored by Institute of Hematology & Blood Diseases Hospital, China. Status unknown at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2013-01-03.
Sponsored by Institute of Hematology & Blood Diseases Hospital, China · Phase 2, Interventional, and Treatment
Paroxysmal nocturnal hemoglobinuria is an acquired chronic hemolytic anemia,this study is designed to evaluate the safety and efficacy of Levamisole combined with cyclosporine A in patients with classic paroxysmal nocturnal hemoglobinuria.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of the hematopoietic stem cell characterized by intravascular hemolysis, hemoglobinuria, anemia, and thrombosis, Patients may be at high risk of thrombosis and may develop bone marrow failure or aplastic anemia, with low white blood cell and platelet counts,because the manifestation and pathologic processes are complicate,the treatment is very difficult,this study is designed to evaluate the safety and efficacy of Levamisole combined with cyclosporine A in patients with classic paroxysmal nocturnal hemoglobinuria
234 studies on the registry are indexed under Proteinuria; 43 are open to participants now.
This study's planned enrollment of 120 is above the median of 60 across 164 interventional studies indexed under Proteinuria.
Browse Proteinuria studies →Institute of Hematology & Blood Diseases Hospital, China is the lead sponsor of 398 studies on the registry; 293 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Levamisole+cyclosporin A+Glucocorticoids
Drug: Levamisole+cyclosporin A+Glucocorticoids
cyclosporin A+Glucocorticoids
Drug: cyclosporin A+Glucocorticoids
Glucocorticoids
Drug: Glucocorticoids
Levamisole 2.5mg/kg every other day cyclosporin A 1.5-2.5mg/kg every other day Glucocorticoids0.5-1mg/kg every day(prednisone)
Also known as: Levamisole, cyclosporin A, Glucocorticoids
cyclosporin A 1.5-2.5mg/kg every day Glucocorticoids0.5-1mg/kg every day(prednisone)
Also known as: cyclosporin A, Glucocorticoids
Glucocorticoids 0.5-1mg/kg every day(prednisone)
Number of patients in each group in complete or partial remission
she got blood transfusion-independent,the hemoglobin became higher
Time frame: 6 months
Side effects
Time frame: 6 months
This study is status unknown, as verified in Jan 2013. You cannot join it, but the record below documents what was studied.
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Institute of Hematology & Blood Diseases Hospital, China